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Gene

PROC

protein C, inactivator of coagulation factors Va and VIIIa

Summary

Cytogenetic location
2q14.3
Coordinates
Chromosome 2: 127,418,427–127,429,242 (GRCh38)
Exons
9 exons across 10.8 kb
Protein
461 amino acids
MANE Select transcript
ENST00000234071.8NM_000312.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Thrombophilia

    • Inherited Thrombophilia
      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      Anticoagulation (duration by genotype); avoid estrogen-containing contraceptives; LMWH for pregnancy prophylaxis; extended post-surgical anticoagulation; lifelong anticoagulation for compound/high-risk genotypes

How PROC is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 2, with a bracket where PROC sits. PROC and 12 genes near it on chromosome 2, from 126,923,835 to 127,923,834.Chromosome 22q14.3p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.3127 Mb127.2 Mb127.4 Mb127.6 Mb127.8 MbBIN1: 127,048,017–127,107,556, reverse strandBIN1CYP27C1: 127,183,832–127,220,385, reverse strandCYP27C1ERCC3: 127,257,285–127,294,188, reverse strandERCC3MAP3K2: 127,298,668–127,388,465, reverse strandMAP3K2PROC: 127,418,427–127,429,242, forward strandPROCIWS1: 127,436,207–127,526,886, reverse strandIWS1MYO7B: 127,535,683–127,637,729, forward strandMYO7BLIMS2: 127,638,381–127,681,786, reverse strandLIMS2GPR17: 127,645,864–127,656,181, forward strandGPR17WDR33: 127,701,027–127,811,195, reverse strandWDR33SFT2D3: 127,701,497–127,705,242, forward strandSFT2D3POLR2D: 127,843,553–127,858,163, reverse strandPOLR2DAMMECR1L: 127,861,630–127,885,967, reverse strandAMMECR1LDiagram of PROC: 9 exons on the forward strand of chromosome 2Exon 2: 2 known disease-causing sitesExon 3: 6 known disease-causing sitesExon 5: 7 known disease-causing sitesExon 6: 8 known disease-causing sitesExon 7: 13 known disease-causing sitesExon 8: 7 known disease-causing sitesExon 9: 28 known disease-causing sitesExon 1: 127,418,427–127,418,492, 66 basesExon 2: 127,419,922–127,420,012, 91 basesExon 3: 127,421,283–127,421,449, 167 basesExon 4: 127,422,917–127,422,941, 25 basesExon 5: 127,423,034–127,423,171, 138 basesExon 6: 127,423,274–127,423,408, 135 basesExon 7: 127,426,085–127,426,227, 143 basesExon 8: 127,427,105–127,427,222, 118 basesExon 9: 127,428,357–127,429,242, 886 bases1234567895′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.8 kb of the gene's 10.8 kb; 1,386 of those bases code for the protein.

How a genome test reads PROC

76

positions in PROC where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 10.8 kb of PROC, introns included, not only the 1.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PROC gene: protein C, inactivator of coagulation factors Va and VIIIa. Retrieved 16 October 2026, from https://dantelabs.com/genes/proc

Vancouver

Dante Labs. PROC gene: protein C, inactivator of coagulation factors Va and VIIIa [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/proc

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