Skip to content
Use your HSA or FSA funds

Gene

DCN

decorin

Summary

Cytogenetic location
12q21.33
Coordinates
Chromosome 12: 91,140,484–91,182,817 (GRCh38)
Exons
8 exons across 42.3 kb
Protein
359 amino acids
Also known as
DSPG2, SLRR1B
MANE Select transcript
ENST00000052754.10NM_001920.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hereditary Corneal Dystrophies

    • Corneal Dystrophy

      A group of inherited conditions affecting one or more layers of the cornea, including Fuchs endothelial dystrophy (often linked to a TCF4 repeat expansion), TGFBI-related granular and lattice dystrophies, and rarer types caused by genes such as SLC4A11, COL8A2, ZEB1 and CHST6.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Carriers of TGFBI variants are generally advised to avoid laser refractive surgery (LASIK or PRK), which can make deposits worse; corneal transplant can restore vision in advanced disease.

How DCN is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 12, with a bracket where DCN sits. DCN and 4 genes near it on chromosome 12, from 90,661,651 to 91,661,650.Chromosome 1212q21.33p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3390.8 Mb91 Mb91.2 Mb91.4 Mb91.6 MbCCER1: 90,905,622–90,955,176, reverse strandCCER1EPYC: 90,963,682–91,005,026, reverse strandEPYCKERA: 91,050,491–91,058,024, reverse strandKERALUM: 91,102,526–91,111,682, reverse strandLUMDCN: 91,140,484–91,182,817, reverse strandDCNDiagram of DCN: 8 exons on the reverse strand of chromosome 12Exon 7: 1 known disease-causing siteExon 8: 91,140,484–91,146,252, 5,769 basesExon 7: 91,151,654–91,151,792, 139 basesExon 6: 91,153,096–91,153,189, 94 basesExon 5: 91,157,075–91,157,188, 114 basesExon 4: 91,158,296–91,158,509, 214 basesExon 3: 91,164,605–91,164,717, 113 basesExon 2: 91,178,342–91,178,585, 244 basesExon 1: 91,182,655–91,182,817, 163 bases876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.9 kb of the gene's 42.3 kb; 1,080 of those bases code for the protein.

How a genome test reads DCN

1

position in DCN where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 42.3 kb of DCN, introns included, not only the 6.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DCN gene: decorin. Retrieved 16 October 2026, from https://dantelabs.com/genes/dcn

Vancouver

Dante Labs. DCN gene: decorin [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/dcn

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test