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Gene

VRK1

VRK serine/threonine kinase 1

Summary

Cytogenetic location
14q32.2
Coordinates
Chromosome 14: 96,797,382–96,881,609 (GRCh38)
Exons
13 exons across 84.2 kb
Protein
396 amino acids
MANE Select transcript
ENST00000216639.8NM_003384.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Charcot-Marie-Tooth Disease

    • Distal Hereditary Motor Neuropathy

      Inherited neuropathies that mainly affect motor nerves, causing weakness and wasting of the hands and feet, including SORD-related neuropathy.

      • 1 GenCC submitter rates it definitive or strong

  • Spinal Muscular Atrophy

    • A group of disorders characterised by degeneration of spinal cord anterior horn cells, leading to progressive muscle weakness and atrophy.

      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      Gene therapy (onasemnogene abeparvovec), antisense oligonucleotide therapy (nusinersen), oral splicing modifier (risdiplam), supportive care

Broader groupings

How VRK1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 14, with a bracket where VRK1 sits. VRK1 and 4 genes near it on chromosome 14, from 96,339,496 to 97,339,495.Chromosome 1414q32.2p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.11q32.12q32.13q32.2q32.31q32.32q32.3396.4 Mb96.6 Mb96.8 Mb97 Mb97.2 MbATG2B: 96,279,195–96,363,422, reverse strandATG2BGSKIP: 96,363,452–96,388,156, forward strandGSKIPAK7: 96,392,097–96,490,031, forward strandAK7PAPOLA: 96,501,433–96,567,118, forward strandPAPOLAVRK1: 96,797,382–96,881,609, forward strandVRK1Diagram of VRK1: 13 exons on the forward strand of chromosome 14Exon 2: 13 known disease-causing sitesExon 3: 3 known disease-causing sitesExon 4: 8 known disease-causing sitesExon 5: 6 known disease-causing sitesExon 6: 9 known disease-causing sitesExon 7: 12 known disease-causing sitesExon 8: 7 known disease-causing sitesExon 9: 8 known disease-causing sitesExon 10: 5 known disease-causing sitesExon 11: 9 known disease-causing sitesExon 12: 12 known disease-causing sitesExon 13: 1 known disease-causing siteExon 1: 96,797,382–96,797,447, 66 basesExon 2: 96,833,467–96,833,631, 165 basesExon 3: 96,837,762–96,837,817, 56 basesExon 4: 96,846,095–96,846,164, 70 basesExon 5: 96,847,257–96,847,344, 88 basesExon 6: 96,852,831–96,852,939, 109 basesExon 7: 96,853,074–96,853,166, 93 basesExon 8: 96,855,224–96,855,356, 133 basesExon 9: 96,856,130–96,856,250, 121 basesExon 10: 96,856,528–96,856,586, 59 basesExon 11: 96,860,557–96,860,735, 179 basesExon 12: 96,876,030–96,876,120, 91 basesExon 13: 96,881,177–96,881,609, 433 bases1510135′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.7 kb of the gene's 84.2 kb; 1,191 of those bases code for the protein.

How a genome test reads VRK1

107

positions in VRK1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 84.2 kb of VRK1, introns included, not only the 1.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). VRK1 gene: VRK serine/threonine kinase 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/vrk1

Vancouver

Dante Labs. VRK1 gene: VRK serine/threonine kinase 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/vrk1

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