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Gene

CFHR3

complement factor H related 3

Summary

Cytogenetic location
1q31.3
Coordinates
Chromosome 1: 196,774,840–196,795,407 (GRCh38)
Exons
6 exons across 20.6 kb
Protein
330 amino acids
Also known as
FHR-3, HLF4, FHR3, DOWN16
Previous symbols
CFHL3
MANE Select transcript
ENST00000367425.9NM_021023.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads CFHR3 yet. The test sequences your whole genome, so your data includes it all the same.

How CFHR3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where CFHR3 sits. CFHR3 and 11 genes near it on chromosome 1, from 196,285,124 to 197,285,123.Chromosome 11q31.3p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44196.4 Mb196.6 Mb196.8 Mb197 Mb197.2 MbKCNT2: 196,225,779–196,609,225, reverse strandKCNT2CFH: 196,651,754–196,753,075, forward strandCFH: 196,651,852–196,795,393, forward strandCFHR3: 196,774,840–196,795,407, forward strandCFHR3CFHR1: 196,819,314–196,837,159, forward strandCFHR1CFHR4: 196,888,014–196,920,294, forward strandCFHR4CFHR2: 196,943,731–196,964,408, forward strandCFHR2CFHR5: 196,975,010–197,009,678, forward strandCFHR5F13B: 197,038,737–197,067,267, reverse strandF13BASPM: 197,084,121–197,146,699, reverse strandASPMZBTB41: 197,153,682–197,201,449, reverse strandZBTB41CRB1: 197,268,195–197,478,455, forward strandCRB1Diagram of CFHR3: 6 exons on the forward strand of chromosome 1Exon 4: 1 known disease-causing siteExon 1: 196,774,840–196,774,944, 105 basesExon 2: 196,779,162–196,779,356, 195 basesExon 3: 196,779,797–196,779,973, 177 basesExon 4: 196,788,216–196,788,398, 183 basesExon 5: 196,790,045–196,790,227, 183 basesExon 6: 196,793,317–196,795,407, 2,091 bases1234565′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.9 kb of the gene's 20.6 kb; 993 of those bases code for the protein.

How a genome test reads CFHR3

1

position in CFHR3 where ClinVar classes a change as pathogenic or likely pathogenic

1 of them (100%) falls in a region short reads find hard.

  • Low mappability (1 site)Regions where 100 bp or 250 bp reads cannot be placed uniquely.
  • Segmental duplications (1 site)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

A whole genome covers all 20.6 kb of CFHR3, introns included, not only the 2.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CFHR3 gene: complement factor H related 3. Retrieved 16 October 2026, from https://dantelabs.com/genes/cfhr3

Vancouver

Dante Labs. CFHR3 gene: complement factor H related 3 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/cfhr3

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