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Gene

ARHGAP29

Rho GTPase activating protein 29

Summary

Cytogenetic location
1p22.1
Coordinates
Chromosome 1: 94,168,905–94,237,584 (GRCh38)
Exons
23 exons across 68.7 kb
Protein
1,261 amino acids
Inheritance
Autosomal dominant
Also known as
PARG1
MANE Select transcript
ENST00000260526.11NM_004815.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hereditary Orofacial Clefting

    • ARHGAP29-related Non-syndromic Orofacial CleftAutosomal dominant

      Cleft lip with or without cleft palate, without other syndromic features, caused by variants in the ARHGAP29 gene.

      • ClinGen rates the link definitive
      • 1 GenCC submitter rates it definitive or strong

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How ARHGAP29 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 1, with a bracket where ARHGAP29 sits. ARHGAP29 and 6 genes near it on chromosome 1, from 93,703,245 to 94,703,244.Chromosome 11p22.1p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q4493.8 Mb94 Mb94.2 Mb94.4 Mb94.6 MbBCAR3: 93,561,178–93,847,488, reverse strandBCAR3DNTTIP2: 93,866,284–93,879,918, reverse strandDNTTIP2GCLM: 93,885,199–93,909,654, reverse strandGCLMABCA4: 93,992,834–94,121,177, reverse strandABCA4ARHGAP29: 94,168,905–94,237,584, reverse strandARHGAP29ABCD3: 94,418,039–94,519,349, forward strandABCD3F3: 94,528,263–94,541,851, reverse strandF3Diagram of ARHGAP29: 23 exons on the reverse strand of chromosome 1Exon 23: 94,168,905–94,174,749, 5,845 basesExon 22: 94,177,612–94,177,720, 109 basesExon 21: 94,177,852–94,178,167, 316 basesExon 20: 94,179,725–94,179,957, 233 basesExon 19: 94,184,151–94,184,288, 138 basesExon 18: 94,184,872–94,185,060, 189 basesExon 17: 94,185,342–94,185,481, 140 basesExon 16: 94,186,499–94,186,597, 99 basesExon 15: 94,188,837–94,188,941, 105 basesExon 14: 94,189,216–94,189,352, 137 basesExon 13: 94,189,926–94,190,083, 158 basesExon 12: 94,201,720–94,201,857, 138 basesExon 11: 94,202,544–94,202,732, 189 basesExon 10: 94,202,918–94,202,998, 81 basesExon 9: 94,203,100–94,203,210, 111 basesExon 8: 94,203,930–94,203,994, 65 basesExon 7: 94,205,061–94,205,198, 138 basesExon 6: 94,205,635–94,205,683, 49 basesExon 5: 94,208,832–94,208,904, 73 basesExon 4: 94,209,254–94,209,350, 97 basesExon 3: 94,220,258–94,220,392, 135 basesExon 2: 94,231,407–94,231,643, 237 basesExon 1: 94,237,415–94,237,584, 170 bases23201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 9 kb of the gene's 68.7 kb; 3,786 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ARHGAP29 gene: Rho GTPase activating protein 29. Retrieved 17 October 2026, from https://dantelabs.com/genes/arhgap29

Vancouver

Dante Labs. ARHGAP29 gene: Rho GTPase activating protein 29 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/arhgap29

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