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Gene

ALDH6A1

aldehyde dehydrogenase 6 family member A1

Summary

Cytogenetic location
14q24.3
Coordinates
Chromosome 14: 74,056,847–74,084,453 (GRCh38)
Exons
12 exons across 27.6 kb
Protein
535 amino acids
Previous symbols
MMSDH
MANE Select transcript
ENST00000553458.6NM_005589.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads ALDH6A1 yet. The test sequences your whole genome, so your data includes it all the same.

How ALDH6A1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 14, with a bracket where ALDH6A1 sits. ALDH6A1 and 21 genes near it on chromosome 14, from 73,570,650 to 74,570,649.Chromosome 1414q24.3p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.11q32.12q32.13q32.2q32.31q32.32q32.3373.6 Mb73.8 Mb74 Mb74.2 Mb74.4 MbACOT2: 73,567,620–73,588,885, forward strandACOT2ACOT4: 73,591,660–73,595,766, forward strandACOT4ACOT6: 73,610,945–73,619,888, forward strandACOT6DNAL1: 73,644,875–73,703,732, forward strandDNAL1PNMA1: 73,711,783–73,714,384, reverse strandPNMA1MIDEAS: 73,715,122–73,790,285, reverse strandMIDEASPTGR2: 73,851,792–73,885,726, forward strandPTGR2: 73,851,971–73,932,278, forward strandZNF410: 73,886,201–73,932,521, forward strandZNF410FAM161B: 73,931,501–73,950,414, reverse strandFAM161BCOQ6: 73,949,926–73,963,670, forward strandCOQ6ENTPD5: 73,956,688–74,019,399, reverse strandENTPD5BBOF1: 74,019,341–74,082,863, forward strandBBOF1ALDH6A1: 74,056,847–74,084,453, reverse strandALDH6A1LIN52: 74,084,943–74,201,493, forward strandLIN52VSX2: 74,239,449–74,262,738, forward strandVSX2ABCD4: 74,285,269–74,303,068, reverse strandABCD4VRTN: 74,303,069–74,360,011, forward strandVRTNSYNDIG1L: 74,405,894–74,426,325, reverse strandSYNDIG1LNPC2: 74,427,119–74,494,177, reverse strandNPC2ISCA2: 74,493,721–74,499,758, forward strandISCA2LTBP2: 74,498,163–74,612,378, reverse strandLTBP2Diagram of ALDH6A1: 12 exons on the reverse strand of chromosome 14Exon 9: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 12: 74,056,847–74,060,746, 3,900 basesExon 11: 74,064,822–74,064,920, 99 basesExon 10: 74,065,181–74,065,360, 180 basesExon 9: 74,066,705–74,066,886, 182 basesExon 8: 74,067,380–74,067,569, 190 basesExon 7: 74,068,860–74,068,981, 122 basesExon 6: 74,071,195–74,071,497, 303 basesExon 5: 74,071,896–74,071,974, 79 basesExon 4: 74,072,203–74,072,364, 162 basesExon 3: 74,072,537–74,072,611, 75 basesExon 2: 74,074,955–74,075,017, 63 basesExon 1: 74,084,347–74,084,453, 107 bases1210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.5 kb of the gene's 27.6 kb; 1,608 of those bases code for the protein.

How a genome test reads ALDH6A1

2

positions in ALDH6A1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 27.6 kb of ALDH6A1, introns included, not only the 5.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ALDH6A1 gene: aldehyde dehydrogenase 6 family member A1. Retrieved 17 October 2026, from https://dantelabs.com/genes/aldh6a1

Vancouver

Dante Labs. ALDH6A1 gene: aldehyde dehydrogenase 6 family member A1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/aldh6a1

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