Gene
HOXA13
homeobox A13
- HGNC 5102↗(opens in a new tab)
- Ensembl gene ENSG00000106031↗(opens in a new tab)
- NCBI Gene 3209↗(opens in a new tab)
Summary
- Cytogenetic location
- 7p15.2
- Coordinates
- Chromosome 7: 27,194,364–27,200,091 (GRCh38)
- Exons
- 2 exons across 5.7 kb
- Protein
- 388 amino acids
- Previous symbols
- HOX1J, HOX1
- MANE Select transcript
- ENST00000649031.1NM_000522.5
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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How HOXA13 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 5 kb of the gene's 5.7 kb; 1,167 of those bases code for the protein.
How a genome test reads HOXA13
4
positions in HOXA13 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 5.7 kb of HOXA13, introns included, not only the 5 kb of exons.
Traits linked to HOXA13
The Human Phenotype Ontology lists these as features of the rare conditions HOXA13 can cause. Each trait's page lists the other genes linked to it.
Abnormality of limbs
- Abnormal scaphoid morphology
- Absent big toe
- Absent distal interphalangeal creases
- Absent outermost little finger bone
- Attachment of thumb close to wrist
- Broad big toe
- Broad distal hallux
- Broad innermost bone of the big toe
Show 37 more traits
- Bunion
- Capitate-hamate fusion
- Club feet
- Curvature of digit
- Curvature of little finger
- Curvature of ring finger
- Dropped arches
- Extra little finger
- Fused ankle bones
- Fused bones of the midfoot
- Fused wrist bones
- Hallux varus
- Short 5th finger
- Short big toe
- Short foot
- Short middle bone of the little finger
- Short outermost bone of ring finger
- Short outermost bone of the index finger
- Short outermost bone of the middle finger
- Short outermost bone of toe
- Short outermost finger bone
- Short second toe
- Short thumb
- Shortened 1st long bone of hand
- Small hand
- Small outermost bone of big toe
- Small thenar eminence
- Tibial deviation of the 3rd toe
- Tibial deviation of the 4th toe
- Tibial deviation of the 5th toe
- Tibial deviation of toes
- Fusion of wrist bones
- Short 1st long bone of foot
- Shortening of all middle phalanges of the fingers
- Delayed ankle bone maturation
- Delayed maturation of wrist bone
- Ulnar deviation of the 2nd finger
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). HOXA13 gene: homeobox A13. Retrieved 17 October 2026, from https://dantelabs.com/genes/hoxa13
Dante Labs. HOXA13 gene: homeobox A13 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/hoxa13
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