Skip to content
Use your HSA or FSA funds

Trait

Chronic pain

Persistent pain, usually defined as pain that has lasted longer than 3 to 6 months.

HPO HP:0012532

Summary

Also called
Long-lasting pain
Body system
Constitutional symptom

14 genes linked to Chronic pain

Changes in these genes cause rare conditions in which Chronic pain is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
TGFB2transforming growth factor beta 2AlwaysIn 1 condition
COL7A1collagen type VII alpha 1 chainVery often (80–99%)In 1 condition
MMP1matrix metallopeptidase 1Very often (80–99%)In 1 condition
CTSKcathepsin KOften (30–79%)In 1 condition
DNMT3BDNA methyltransferase 3 betaOften (30–79%)In 1 condition
DUX4double homeobox 4Often (30–79%)In 1 condition
DUX4L1double homeobox 4 like 1 (pseudogene)Often (30–79%)In 1 condition
FRG1FSHD region gene 1Often (30–79%)In 1 condition
GLAgalactosidase alphaOften (30–79%)In 1 condition
SMCHD1structural maintenance of chromosomes flexible hinge domain containing 1Often (30–79%)In 1 condition
FLVCR1FLVCR choline and heme transporter 1Sometimes (5–29%)In 1 condition
TAFAZZINtafazzin, phospholipid-lysophospholipid transacylaseSometimes (5–29%)In 1 condition
ZFXzinc finger protein X-linkedSometimes (5–29%)In 1 condition
ATXN3ataxin 3Not recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Pain

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test