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Gene

DNAJB4

DnaJ heat shock protein family (Hsp40) member B4

Summary

Cytogenetic location
1p31.1
Coordinates
Chromosome 1: 78,004,939–78,017,964 (GRCh38)
Exons
3 exons across 13 kb
Protein
337 amino acids
Also known as
HLJ1
MANE Select transcript
ENST00000370763.6NM_007034.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Distal Myopathies

    • Distal myopathy

      A group of inherited muscle disorders in which weakness starts in the hands, forearms, lower legs or feet, caused by genes such as TTN, DYSF, FLNC, MYH7, ADSS1, SMPX and MATR3.

      • 1 GenCC submitter rates it definitive or strong

How DNAJB4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 1, with a bracket where DNAJB4 sits. DNAJB4 and 8 genes near it on chromosome 1, from 77,511,452 to 78,511,451.Chromosome 11p31.1p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q4477.6 Mb77.8 Mb78 Mb78.2 Mb78.4 MbAK5: 77,281,853–77,559,966, forward strandAK5ZZZ3: 77,562,416–77,683,550, reverse strandZZZ3USP33: 77,694,724–77,759,904, reverse strandUSP33MIGA1: 77,779,619–77,879,595, forward strandMIGA1NEXN: 77,888,174–77,943,898, forward strandNEXNFUBP1: 77,944,055–77,979,527, reverse strandFUBP1GIPC2: 77,979,542–78,138,463, forward strandGIPC2DNAJB4: 78,004,939–78,017,964, forward strandDNAJB4PTGFR: 78,303,884–78,540,701, forward strandPTGFRDiagram of DNAJB4: 3 exons on the forward strand of chromosome 1Exon 1: 78,004,939–78,005,321, 383 basesExon 2: 78,013,051–78,013,619, 569 basesExon 3: 78,016,014–78,017,964, 1,951 bases1235′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.9 kb of the gene's 13 kb; 1,014 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DNAJB4 gene: DnaJ heat shock protein family (Hsp40) member B4. Retrieved 17 October 2026, from https://dantelabs.com/genes/dnajb4

Vancouver

Dante Labs. DNAJB4 gene: DnaJ heat shock protein family (Hsp40) member B4 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/dnajb4

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