Trait
Scaling skin
Refers to the loss of the outer layer of the epidermis in large, scale-like flakes.
Summary
- Also called
- flaking skin, peeling skin, Scaly skin, Desquamation
- Body system
- Abnormality of the integument
Reference genomeGRCh38hg38
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Get my Genome Test45 genes linked to Scaling skin
Changes in these genes cause rare conditions in which Scaling skin is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CASTcalpastatin | Always | In 1 condition |
| CDSNcorneodesmosin | Always | In 2 conditions |
| DCLRE1CDNA cross-link repair 1C | Always | In 1 condition |
| DONSONDNA replication fork stabilization factor DONSON | Always | In 1 condition |
| ELOVL4ELOVL fatty acid elongase 4 | Always | In 1 condition |
| FLG2filaggrin 2 | Always | In 1 condition |
| IL2RAinterleukin 2 receptor subunit alpha | Always | In 1 condition |
| KRT1keratin 1 | Always | In 3 conditions |
| KRT10keratin 10 | Always | In 2 conditions |
| MPV17mitochondrial inner membrane protein MPV17 | Always | In 1 condition |
| PKP1plakophilin 1 | Always | In 2 conditions |
| PPP2R3Cprotein phosphatase 2 regulatory subunit B''gamma | Always | In 1 condition |
| RAG1recombination activating 1 | Always | In 1 condition |
| RAG2recombination activating 2 | Always | In 1 condition |
| SERPINB8serpin family B member 8 | Always | In 1 condition |
| SPINK5serine peptidase inhibitor Kazal type 5 | Always | In 1 condition |
| SULT2B1sulfotransferase family 2B member 1 | Always | In 1 condition |
| TGM5transglutaminase 5 | Always | In 2 conditions |
| ZMPSTE24zinc metallopeptidase STE24 | Always | In 2 conditions |
| LMNAlamin A/C | Very often (80–99%) | In 1 condition |
| TGM1transglutaminase 1 | Very often (80–99%) | In 1 condition |
| ADAM17ADAM metallopeptidase domain 17 | Often (30–79%) | In 1 condition |
| CARMIL2capping protein regulator and myosin 1 linker 2 | Often (30–79%) | In 1 condition |
| CSTAcystatin A | Often (30–79%) | In 2 conditions |
| EBPEBP cholestenol delta-isomerase | Often (30–79%) | In 1 condition |
| GJB2gap junction protein beta 2 | Often (30–79%) | In 1 condition |
| GJB6gap junction protein beta 6 | Often (30–79%) | In 1 condition |
| LDHAlactate dehydrogenase A | Often (30–79%) | In 1 condition |
| RECQLRecQ like helicase | Often (30–79%) | In 1 condition |
| SASH1SAM and SH3 domain containing 1 | Often (30–79%) | In 1 condition |
| DCAF17DDB1 and CUL4 associated factor 17 | Sometimes (5–29%) | In 1 condition |
| GJA1gap junction protein alpha 1 | Sometimes (5–29%) | In 1 condition |
| GNB2G protein subunit beta 2 | Sometimes (5–29%) | In 1 condition |
| KIF11kinesin family member 11 | Sometimes (5–29%) | In 1 condition |
| KITKIT proto-oncogene, receptor tyrosine kinase | Sometimes (5–29%) | In 1 condition |
| KRT74keratin 74 | Sometimes (5–29%) | In 1 condition |
| MPDU1mannose-P-dolichol utilization defect 1 | Sometimes (5–29%) | In 2 conditions |
| RASA1RAS p21 protein activator 1 | Sometimes (5–29%) | In 1 condition |
| RNF168ring finger protein 168 | Sometimes (5–29%) | In 1 condition |
| CARD14caspase recruitment domain family member 14 | Not recorded | In 1 condition |
Show 5 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| KLK11kallikrein related peptidase 11 | Not recorded | In 1 condition |
| MBTPS2membrane bound transcription factor peptidase, site 2 | Not recorded | In 1 condition |
| NIPAL4NIPA like domain containing 4 | Not recorded | In 1 condition |
| OSMRoncostatin M receptor | Not recorded | In 1 condition |
| SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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