Trait
Red scaly skin caused by inflammatory skin disease
Clinical name: Erythroderma
An inflammatory exfoliative dermatosis involving nearly all of the surface of the skin. Erythroderma develops suddenly. A patchy erythema may generalize and spread to affect most of the skin. Scaling may appear in 2-6 days and be accompanied by hot, red, dry skin, malaise, and fever.
Summary
- Also called
- Exfoliative dermititis, Generalised erythroderma, Generalised erythrodermia, Generalized erythroderma, Generalized erythrodermia
Reference genomeGRCh38hg38
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Get my Genome Test61 genes linked to Red scaly skin caused by inflammatory skin disease
Changes in these genes cause rare conditions in which Red scaly skin caused by inflammatory skin disease is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ADAM17ADAM metallopeptidase domain 17 | Always | In 1 condition |
| AK2adenylate kinase 2 | Always | In 1 condition |
| AP1B1adaptor related protein complex 1 subunit beta 1 | Always | In 1 condition |
| CD247CD247 molecule | Always | In 2 conditions |
| CDSNcorneodesmosin | Always | In 1 condition |
| CERS3ceramide synthase 3 | Always | In 2 conditions |
| DSG1desmoglein 1 | Always | In 1 condition |
| GJB2gap junction protein beta 2 | Always | In 1 condition |
| GJB3gap junction protein beta 3 | Always | In 1 condition |
| IL2RAinterleukin 2 receptor subunit alpha | Always | In 1 condition |
| KLK11kallikrein related peptidase 11 | Always | In 1 condition |
| KRT10keratin 10 | Always | In 4 conditions |
| PNPLA1patatin like domain 1, omega-hydroxyceramide transacylase | Always | In 2 conditions |
| POLD3DNA polymerase delta 3, accessory subunit | Always | In 1 condition |
| SLC27A4solute carrier family 27 member 4 | Always | In 1 condition |
| ABCA12ATP binding cassette subfamily A member 12 | Very often (80–99%) | In 3 conditions |
| ADAadenosine deaminase | Very often (80–99%) | In 1 condition |
| ALOX12Barachidonate 12-lipoxygenase, 12R type | Very often (80–99%) | In 2 conditions |
| ALOXE3arachidonate epidermal lipoxygenase 3 | Very often (80–99%) | In 2 conditions |
| AP1S3adaptor related protein complex 1 subunit sigma 3 | Very often (80–99%) | In 1 condition |
| CARD14caspase recruitment domain family member 14 | Very often (80–99%) | In 1 condition |
| CD28CD28 molecule | Very often (80–99%) | In 2 conditions |
| CHD7chromodomain helicase DNA binding protein 7 | Very often (80–99%) | In 1 condition |
| CTLA4cytotoxic T-lymphocyte associated protein 4 | Very often (80–99%) | In 2 conditions |
| DCLRE1CDNA cross-link repair 1C | Very often (80–99%) | In 2 conditions |
| IL2RGinterleukin 2 receptor subunit gamma | Very often (80–99%) | In 1 condition |
| IL36RNinterleukin 36 receptor antagonist | Very often (80–99%) | In 1 condition |
| IL7Rinterleukin 7 receptor | Very often (80–99%) | In 2 conditions |
| KITKIT proto-oncogene, receptor tyrosine kinase | Very often (80–99%) | In 1 condition |
| KRT1keratin 1 | Very often (80–99%) | In 2 conditions |
| NIPAL4NIPA like domain containing 4 | Very often (80–99%) | In 3 conditions |
| NUDCD3NudC domain containing 3 | Very often (80–99%) | In 1 condition |
| PSMB10proteasome 20S subunit beta 10 | Very often (80–99%) | In 1 condition |
| RAG1recombination activating 1 | Very often (80–99%) | In 2 conditions |
| RAG2recombination activating 2 | Very often (80–99%) | In 2 conditions |
| RMRPRNA component of mitochondrial RNA processing endoribonuclease | Very often (80–99%) | In 1 condition |
| SDR9C7short chain dehydrogenase/reductase family 9C member 7 | Very often (80–99%) | In 2 conditions |
| SPINK5serine peptidase inhibitor Kazal type 5 | Very often (80–99%) | In 1 condition |
| SULT2B1sulfotransferase family 2B member 1 | Very often (80–99%) | In 2 conditions |
| TGM1transglutaminase 1 | Very often (80–99%) | In 4 conditions |
Show 21 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| TNFRSF1BTNF receptor superfamily member 1B | Very often (80–99%) | In 2 conditions |
| EBPEBP cholestenol delta-isomerase | Often (30–79%) | In 2 conditions |
| ELOVL4ELOVL fatty acid elongase 4 | Often (30–79%) | In 1 condition |
| PRF1perforin 1 | Often (30–79%) | In 1 condition |
| RBCK1RANBP2-type and C3HC4-type zinc finger containing 1 | Often (30–79%) | In 1 condition |
| STX11syntaxin 11 | Often (30–79%) | In 1 condition |
| STXBP2syntaxin binding protein 2 | Often (30–79%) | In 1 condition |
| TOM1target of myb1 membrane trafficking protein | Often (30–79%) | In 1 condition |
| UNC13Dunc-13 homolog D | Often (30–79%) | In 1 condition |
| ASPRV1aspartic peptidase retroviral like 1 | Sometimes (5–29%) | In 1 condition |
| CD3DCD3 delta subunit of T-cell receptor complex | Sometimes (5–29%) | In 1 condition |
| CD3ECD3 epsilon subunit of T-cell receptor complex | Sometimes (5–29%) | In 1 condition |
| CYP4F22cytochrome P450 family 4 subfamily F member 22 | Sometimes (5–29%) | In 2 conditions |
| DIP2BDIP2 acetate--CoA ligase B (putative) | Sometimes (5–29%) | In 1 condition |
| EXTL3exostosin like glycosyltransferase 3 | Sometimes (5–29%) | In 1 condition |
| FOXP3forkhead box P3 | Sometimes (5–29%) | In 1 condition |
| LIPNlipase family member N | Sometimes (5–29%) | In 1 condition |
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Not recorded | In 1 condition |
| LSSlanosterol synthase | Not recorded | In 1 condition |
| MBTPS2membrane bound transcription factor peptidase, site 2 | Not recorded | In 1 condition |
| MPDU1mannose-P-dolichol utilization defect 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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