Trait
Skin plaque
A plaque is a solid, raised, plateau-like (flat-topped) lesion greater than 1 cm in diameter.
Summary
- Body system
- Abnormality of the integument
Reference genomeGRCh38hg38
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Get my Genome Test35 genes linked to Skin plaque
Changes in these genes cause rare conditions in which Skin plaque is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| GJB4gap junction protein beta 4 | Always | In 1 condition |
| PSMB8proteasome 20S subunit beta 8 | Always | In 1 condition |
| SPINK5serine peptidase inhibitor Kazal type 5 | Always | In 1 condition |
| CD28CD28 molecule | Very often (80–99%) | In 1 condition |
| CIB1calcium and integrin binding 1 | Very often (80–99%) | In 1 condition |
| CTLA4cytotoxic T-lymphocyte associated protein 4 | Very often (80–99%) | In 1 condition |
| IL7interleukin 7 | Very often (80–99%) | In 1 condition |
| KDSR3-ketodihydrosphingosine reductase | Very often (80–99%) | In 1 condition |
| KRT83keratin 83 | Very often (80–99%) | In 1 condition |
| LAMA3laminin subunit alpha 3 | Very often (80–99%) | In 1 condition |
| LAMB3laminin subunit beta 3 | Very often (80–99%) | In 1 condition |
| LAMC2laminin subunit gamma 2 | Very often (80–99%) | In 1 condition |
| LORICRINloricrin cornified envelope precursor protein | Very often (80–99%) | In 1 condition |
| TMC6transmembrane channel like 6 | Very often (80–99%) | In 1 condition |
| TMC8transmembrane channel like 8 | Very often (80–99%) | In 1 condition |
| TNFRSF1BTNF receptor superfamily member 1B | Very often (80–99%) | In 1 condition |
| TRPM4transient receptor potential cation channel subfamily M member 4 | Very often (80–99%) | In 1 condition |
| ATP2A2ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 | Often (30–79%) | In 1 condition |
| COL7A1collagen type VII alpha 1 chain | Often (30–79%) | In 1 condition |
| GJB2gap junction protein beta 2 | Often (30–79%) | In 1 condition |
| GJB6gap junction protein beta 6 | Often (30–79%) | In 1 condition |
| IFNGinterferon gamma | Often (30–79%) | In 1 condition |
| KITKIT proto-oncogene, receptor tyrosine kinase | Often (30–79%) | In 1 condition |
| KRT14keratin 14 | Often (30–79%) | In 1 condition |
| KRT5keratin 5 | Often (30–79%) | In 1 condition |
| TSC1TSC complex subunit 1 | Often (30–79%) | In 1 condition |
| TSC2TSC complex subunit 2 | Often (30–79%) | In 1 condition |
| BTNL2butyrophilin like 2 | Sometimes (5–29%) | In 1 condition |
| CCDC91coiled-coil domain containing 91 | Sometimes (5–29%) | In 1 condition |
| CFTRCF transmembrane conductance regulator | Sometimes (5–29%) | In 1 condition |
| ECM1extracellular matrix protein 1 | Sometimes (5–29%) | In 1 condition |
| GLMNglomulin, FKBP associated protein | Sometimes (5–29%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Sometimes (5–29%) | In 1 condition |
| IDH1isocitrate dehydrogenase (NADP(+)) 1 | Sometimes (5–29%) | In 1 condition |
| UBA1ubiquitin like modifier activating enzyme 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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