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Gene

ADAM17

ADAM metallopeptidase domain 17

Summary

Cytogenetic location
2p25.1
Coordinates
Chromosome 2: 9,488,486–9,555,830 (GRCh38)
Exons
19 exons across 67.3 kb
Protein
824 amino acids
Also known as
cSVP, CD156B
Previous symbols
TACE
MANE Select transcript
ENST00000310823.8NM_003183.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Inflammatory Bowel Diseases (IBD)

    • Inflammatory Bowel Disease

      A spectrum of small and large bowel inflammatory diseases of unknown etiology. It includes Crohn's disease, ulcerative colitis, and colitis of indeterminate type.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong

How ADAM17 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 2, with a bracket where ADAM17 sits. ADAM17 and 7 genes near it on chromosome 2, from 9,022,158 to 10,022,157.Chromosome 22p25.1p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.39.2 Mb9.4 Mb9.6 Mb9.8 Mb10 MbASAP2: 9,206,602–9,405,683, forward strandASAP2ITGB1BP1: 9,402,707–9,423,891, reverse strandITGB1BP1CPSF3: 9,423,623–9,473,117, forward strandCPSF3IAH1: 9,473,658–9,500,587, forward strandIAH1ADAM17: 9,488,486–9,555,830, reverse strandADAM17YWHAQ: 9,583,334–9,639,472, reverse strandYWHAQTAF1B: 9,843,340–9,934,994, forward strandTAF1BGRHL1: 9,951,678–10,002,355, forward strandGRHL1Diagram of ADAM17: 19 exons on the reverse strand of chromosome 2Exon 16: 2 known disease-causing sitesExon 15: 1 known disease-causing siteExon 13: 2 known disease-causing sitesExon 12: 2 known disease-causing sitesExon 11: 1 known disease-causing siteExon 10: 1 known disease-causing siteExon 9: 2 known disease-causing sitesExon 7: 2 known disease-causing sitesExon 6: 2 known disease-causing sitesExon 3: 1 known disease-causing siteExon 19: 9,488,486–9,490,518, 2,033 basesExon 18: 9,491,101–9,491,151, 51 basesExon 17: 9,492,898–9,492,986, 89 basesExon 16: 9,493,747–9,493,825, 79 basesExon 15: 9,494,637–9,494,767, 131 basesExon 14: 9,497,114–9,497,248, 135 basesExon 13: 9,502,173–9,502,276, 104 basesExon 12: 9,505,166–9,505,365, 200 basesExon 11: 9,509,979–9,510,131, 153 basesExon 10: 9,517,901–9,517,989, 89 basesExon 9: 9,518,103–9,518,247, 145 basesExon 8: 9,521,203–9,521,316, 114 basesExon 7: 9,523,249–9,523,338, 90 basesExon 6: 9,526,111–9,526,244, 134 basesExon 5: 9,527,786–9,527,954, 169 basesExon 4: 9,535,834–9,535,922, 89 basesExon 3: 9,536,698–9,536,828, 131 basesExon 2: 9,543,153–9,543,285, 133 basesExon 1: 9,555,509–9,555,830, 322 bases191816141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.4 kb of the gene's 67.3 kb; 2,475 of those bases code for the protein.

How a genome test reads ADAM17

22

positions in ADAM17 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 67.3 kb of ADAM17, introns included, not only the 4.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ADAM17 gene: ADAM metallopeptidase domain 17. Retrieved 17 October 2026, from https://dantelabs.com/genes/adam17

Vancouver

Dante Labs. ADAM17 gene: ADAM metallopeptidase domain 17 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/adam17

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