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Gene

IL10RA

interleukin 10 receptor subunit alpha

Summary

Cytogenetic location
11q23.3
Coordinates
Chromosome 11: 117,986,394–118,001,483 (GRCh38)
Exons
7 exons across 15.1 kb
Protein
578 amino acids
Also known as
HIL-10R, CDW210A, CD210a, CD210
Previous symbols
IL10R
MANE Select transcript
ENST00000227752.8NM_001558.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Inflammatory Bowel Diseases (IBD)

    • Inflammatory Bowel Disease

      A spectrum of small and large bowel inflammatory diseases of unknown etiology. It includes Crohn's disease, ulcerative colitis, and colitis of indeterminate type.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong

Broader groupings

  • Other Inborn Errors of Immunity

    • Inborn error of immunity

      One of 114 genes linked to it

      Inherited disorders of the immune system caused by changes in single genes, affecting how the body fights infection or regulates inflammation.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong

How IL10RA is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 11, with a bracket where IL10RA sits. IL10RA and 19 genes near it on chromosome 11, from 117,493,939 to 118,493,938.Chromosome 1111q23.3p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q25117.6 Mb117.8 Mb118 Mb118.2 Mb118.4 MbDSCAML1: 117,427,772–117,817,525, reverse strandDSCAML1FXYD2: 117,800,839–117,828,734, reverse strandFXYD2FXYD6-FXYD2: 117,820,163–117,876,667, reverse strandFXYD6-FXYD2FXYD6: 117,833,023–117,877,675, reverse strandFXYD6TMPRSS13: 117,900,641–117,929,459, reverse strandTMPRSS13IL10RA: 117,986,394–118,001,483, forward strandIL10RASMIM35: 118,003,634–118,088,299, reverse strandSMIM35TMPRSS4: 118,076,986–118,125,510, forward strandTMPRSS4SCN4B: 118,133,377–118,152,906, reverse strandSCN4BSCN2B: 118,162,806–118,176,653, reverse strandSCN2BJAML: 118,193,725–118,226,323, reverse strandJAMLMPZL3: 118,226,690–118,252,375, reverse strandMPZL3MPZL2: 118,253,416–118,264,536, reverse strandMPZL2CD3E: 118,304,701–118,316,175, forward strandCD3ECD3D: 118,334,537–118,342,713, reverse strandCD3DCD3G: 118,344,338–118,355,161, forward strandCD3GUBE4A: 118,359,578–118,399,211, forward strandUBE4AATP5MG: 118,401,345–118,433,278, forward strandATP5MG: 118,401,602–118,482,737, forward strandKMT2A: 118,436,456–118,526,832, forward strandKMT2ADiagram of IL10RA: 7 exons on the forward strand of chromosome 11Exon 1: 1 known disease-causing siteExon 2: 3 known disease-causing sitesExon 3: 4 known disease-causing sitesExon 4: 6 known disease-causing sitesExon 5: 2 known disease-causing sitesExon 6: 4 known disease-causing sitesExon 1: 117,986,394–117,986,534, 141 basesExon 2: 117,988,382–117,988,502, 121 basesExon 3: 117,989,442–117,989,620, 179 basesExon 4: 117,993,241–117,993,410, 170 basesExon 5: 117,993,999–117,994,149, 151 basesExon 6: 117,995,589–117,995,710, 122 basesExon 7: 117,998,715–118,001,483, 2,769 bases12345675′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.7 kb of the gene's 15.1 kb; 1,737 of those bases code for the protein.

How a genome test reads IL10RA

23

positions in IL10RA where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 15.1 kb of IL10RA, introns included, not only the 3.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). IL10RA gene: interleukin 10 receptor subunit alpha. Retrieved 17 October 2026, from https://dantelabs.com/genes/il10ra

Vancouver

Dante Labs. IL10RA gene: interleukin 10 receptor subunit alpha [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/il10ra

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