Trait
Villous atrophy
The enteric villi are atrophic or absent.
Summary
- Also called
- Atrophy of small intestinal villi, Villous degeneration
- Body system
- Abnormality of the digestive system
Reference genomeGRCh38hg38
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Get my Genome Test29 genes linked to Villous atrophy
Changes in these genes cause rare conditions in which Villous atrophy is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ALG9ALG9 alpha-1,2-mannosyltransferase | Always | In 2 conditions |
| DGAT1diacylglycerol O-acyltransferase 1 | Always | In 1 condition |
| EPCAMepithelial cell adhesion molecule | Always | In 2 conditions |
| IL2RAinterleukin 2 receptor subunit alpha | Always | In 1 condition |
| MPImannose phosphate isomerase | Always | In 1 condition |
| PTCRApre T cell antigen receptor alpha | Always | In 1 condition |
| SKIC3SKI3 subunit of superkiller complex | Always | In 2 conditions |
| STX3syntaxin 3 | Always | In 2 conditions |
| ADAM17ADAM metallopeptidase domain 17 | Often (30–79%) | In 1 condition |
| DEF6DEF6 guanine nucleotide exchange factor | Often (30–79%) | In 1 condition |
| FOXP3forkhead box P3 | Often (30–79%) | In 1 condition |
| LRBALPS responsive beige-like anchor protein | Often (30–79%) | In 1 condition |
| MYO5Bmyosin VB | Often (30–79%) | In 2 conditions |
| PERCC1proline and glutamate rich with coiled coil 1 | Often (30–79%) | In 1 condition |
| PMM2phosphomannomutase 2 | Often (30–79%) | In 1 condition |
| SKIC2SKI2 subunit of superkiller complex | Often (30–79%) | In 2 conditions |
| STAT1signal transducer and activator of transcription 1 | Often (30–79%) | In 2 conditions |
| TBK1TANK binding kinase 1 | Often (30–79%) | In 1 condition |
| TOM1target of myb1 membrane trafficking protein | Often (30–79%) | In 1 condition |
| UNC45Aunc-45 myosin chaperone A | Often (30–79%) | In 1 condition |
| DPYSdihydropyrimidinase | Sometimes (5–29%) | In 1 condition |
| SLC9A3solute carrier family 9 member A3 | Sometimes (5–29%) | In 1 condition |
| SYKspleen associated tyrosine kinase | Sometimes (5–29%) | In 1 condition |
| ALG3ALG3 alpha-1,3- mannosyltransferase | Not recorded | In 1 condition |
| CIITAclass II major histocompatibility complex transactivator | Not recorded | In 1 condition |
| NLRC4NLR family CARD domain containing 4 | Not recorded | In 1 condition |
| PCSK1proprotein convertase subtilisin/kexin type 1 | Not recorded | In 1 condition |
| SPINK5serine peptidase inhibitor Kazal type 5 | Not recorded | In 1 condition |
| WNT2BWnt family member 2B | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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