Trait
Reduced factor XI activity
Decreased activity of coagulation factor XI. Factor XI, also known as plasma thromboplastin antecedent, is a serine proteinase that activates factor IX.
Summary
- Also called
- Low factor XI activity
Reference genomeGRCh38hg38
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Read the genes linked to Reduced factor XI activity, and the rest of your genome, with one test.
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Get my Genome Test13 genes linked to Reduced factor XI activity
Changes in these genes cause rare conditions in which Reduced factor XI activity is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ALG2ALG2 alpha-1,3/1,6-mannosyltransferase | Always | In 1 condition |
| ALG8ALG8 alpha-1,3-glucosyltransferase | Always | In 2 conditions |
| ALG9ALG9 alpha-1,2-mannosyltransferase | Always | In 1 condition |
| SLC37A4solute carrier family 37 member 4 | Always | In 1 condition |
| SOS1SOS Ras/Rac guanine nucleotide exchange factor 1 | Always | In 1 condition |
| F11coagulation factor XI | Very often (80–99%) | In 2 conditions |
| ALG12ALG12 alpha-1,6-mannosyltransferase | Often (30–79%) | In 1 condition |
| LZTR1leucine zipper like post translational regulator 1 | Often (30–79%) | In 1 condition |
| MPImannose phosphate isomerase | Often (30–79%) | In 2 conditions |
| ALG6ALG6 alpha-1,3-glucosyltransferase | Sometimes (5–29%) | In 2 conditions |
| MGAT2alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | Sometimes (5–29%) | In 2 conditions |
| NGLY1N-glycanase 1 | Sometimes (5–29%) | In 1 condition |
| PMM2phosphomannomutase 2 | Sometimes (5–29%) | In 2 conditions |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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