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Gene

BTG4

BTG anti-proliferation factor 4

Summary

Cytogenetic location
11q23.1
Coordinates
Chromosome 11: 111,494,815–111,512,386 (GRCh38)
Exons
5 exons across 17.6 kb
Protein
229 amino acids
Also known as
PC3B, APRO3
MANE Select transcript
ENST00000692032.1NM_001367975.1
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Female Infertility

    • inherited oocyte maturation defect
      • 2 GenCC submitters rate it definitive or strong

How BTG4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 11, with a bracket where BTG4 sits. BTG4 and 16 genes near it on chromosome 11, from 111,003,601 to 112,003,600.Chromosome 1111q23.1p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q25111.2 Mb111.4 Mb111.6 Mb111.8 Mb112 MbPOU2AF2: 111,245,725–111,286,401, forward strandPOU2AF2POU2AF3: 111,298,546–111,308,735, forward strandPOU2AF3POU2AF1: 111,352,255–111,455,630, reverse strandPOU2AF1BTG4: 111,494,815–111,512,386, reverse strandBTG4HOATZ: 111,514,763–111,537,043, forward strandHOATZLAYN: 111,540,280–111,565,625, forward strandLAYNSIK2: 111,602,383–111,730,855, forward strandSIK2PPP2R1B: 111,726,908–111,766,713, reverse strandPPP2R1BALG9: 111,782,195–111,872,405, reverse strandALG9: 111,786,286–111,879,425, reverse strandFDXACB1: 111,873,947–111,881,243, reverse strandFDXACB1CFAP68: 111,878,935–111,885,975, forward strandCFAP68CRYAB: 111,908,239–111,923,722, reverse strandCRYABHSPB2: 111,912,159–111,915,098, forward strandHSPB2HSPB2-C11orf52: 111,912,736–111,926,871, forward strandC11orf52: 111,918,032–111,926,873, forward strandDIXDC1: 111,927,144–112,023,091, forward strandDiagram of BTG4: 5 exons on the reverse strand of chromosome 11Exon 2: 2 known disease-causing sitesExon 5: 111,494,815–111,495,314, 500 basesExon 4: 111,497,211–111,497,409, 199 basesExon 3: 111,497,998–111,498,135, 138 basesExon 2: 111,498,604–111,498,802, 199 basesExon 1: 111,512,181–111,512,386, 206 bases543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.2 kb of the gene's 17.6 kb; 690 of those bases code for the protein.

How a genome test reads BTG4

2

positions in BTG4 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 17.6 kb of BTG4, introns included, not only the 1.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). BTG4 gene: BTG anti-proliferation factor 4. Retrieved 17 October 2026, from https://dantelabs.com/genes/btg4

Vancouver

Dante Labs. BTG4 gene: BTG anti-proliferation factor 4 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/btg4

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