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Gene

IL37

interleukin 37

Summary

Cytogenetic location
2q14.1
Coordinates
Chromosome 2: 112,911,165–112,918,882 (GRCh38)
Exons
6 exons across 7.7 kb
Protein
218 amino acids
Also known as
FIL1, FIL1Z, FIL1(ZETA), IL-1H4, IL-1RP1, IL-1F7
Previous symbols
IL1F7
MANE Select transcript
ENST00000263326.8NM_014439.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads IL37 yet. The test sequences your whole genome, so your data includes it all the same.

How IL37 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 2, with a bracket where IL37 sits. IL37 and 17 genes near it on chromosome 2, from 112,415,024 to 113,415,023.Chromosome 22q14.1p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.3112.6 Mb112.8 Mb113 Mb113.2 Mb113.4 MbRGPD8: 112,368,369–112,434,488, reverse strandRGPD8TTL: 112,482,112–112,541,739, forward strandTTLPOLR1B: 112,541,915–112,579,818, forward strandPOLR1BCHCHD5: 112,584,240–112,589,275, forward strandCHCHD5SLC20A1: 112,645,853–112,664,727, forward strandSLC20A1NT5DC4: 112,721,020–112,742,879, forward strandNT5DC4CKAP2L: 112,736,349–112,764,664, reverse strandCKAP2LIL1A: 112,773,916–112,784,500, reverse strandIL1AIL1B: 112,829,750–112,864,235, reverse strandIL1BIL37: 112,911,165–112,918,882, forward strandIL37IL36G: 112,973,203–112,985,672, forward strandIL36GIL36A: 113,005,459–113,008,044, forward strandIL36AIL36B: 113,022,089–113,052,867, reverse strandIL36BIL36RN: 113,058,638–113,065,382, forward strandIL36RNIL38: 113,067,970–113,075,843, forward strandIL38IL1RN: 113,099,315–113,134,016, forward strandIL1RNPSD4: 113,157,325–113,209,396, forward strandPSD4PAX8: 113,215,997–113,279,001, reverse strandPAX8Diagram of IL37: 6 exons on the forward strand of chromosome 2Exon 3: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 1: 112,911,165–112,911,248, 84 basesExon 2: 112,912,963–112,913,094, 132 basesExon 3: 112,913,792–112,913,854, 63 basesExon 4: 112,917,129–112,917,248, 120 basesExon 5: 112,917,635–112,917,777, 143 basesExon 6: 112,918,561–112,918,882, 322 bases1234565′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 0.9 kb of the gene's 7.7 kb; 657 of those bases code for the protein.

How a genome test reads IL37

2

positions in IL37 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 7.7 kb of IL37, introns included, not only the 0.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). IL37 gene: interleukin 37. Retrieved 16 October 2026, from https://dantelabs.com/genes/il37

Vancouver

Dante Labs. IL37 gene: interleukin 37 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/il37

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