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Gene

ITGB2

integrin subunit beta 2

Summary

Cytogenetic location
21q22.3
Coordinates
Chromosome 21: 44,885,953–44,920,899 (GRCh38)
Exons
16 exons across 34.9 kb
Protein
769 amino acids
Inheritance
Autosomal recessive
Also known as
LFA-1, MAC-1
Previous symbols
CD18, MFI7
MANE Select transcript
ENST00000652462.1NM_000211.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Leukocyte Adhesion Deficiency

    • Autosomal recessive

      Defective white cell adhesion caused by changes in both copies of ITGB2, SLC35C1 or FERMT3.

      • 4 GenCC submitters rate it definitive or strong
      What knowing changes

      Severe forms are treated with stem cell transplantation; type 2 may respond to oral fucose, and antibiotic prophylaxis and dental care reduce infections.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How ITGB2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 21, with a bracket where ITGB2 sits. ITGB2 and 25 genes near it on chromosome 21, from 44,403,426 to 45,403,425.Chromosome 2121q22.3p13p12p11.2p11.1q11.1q11.2q21.1q21.2q21.3q22.11q22.12q22.13q22.2q22.344.6 Mb44.8 Mb45 Mb45.2 Mb45.4 MbTRPM2: 44,350,072–44,445,246, forward strandTRPM2LRRC3: 44,455,472–44,463,452, forward strandLRRC3TSPEAR: 44,497,893–44,712,286, reverse strandKRTAP10-1: 44,538,981–44,540,195, reverse strandKRTAP10-2: 44,550,357–44,551,505, reverse strandKRTAP10-3: 44,557,790–44,558,795, reverse strandKRTAP10-3KRTAP10-4: 44,573,729–44,575,371, forward strandKRTAP10-5: 44,579,455–44,580,604, reverse strandKRTAP10-5KRTAP10-6: 44,591,268–44,592,505, reverse strandKRTAP10-7: 44,600,597–44,602,174, forward strandKRTAP10-8: 44,612,079–44,612,954, forward strandKRTAP10-9: 44,627,093–44,628,378, forward strandKRTAP10-10: 44,637,356–44,638,455, forward strandKRTAP10-11: 44,646,414–44,647,650, forward strandKRTAP12-4: 44,654,213–44,654,659, reverse strandKRTAP12-3: 44,657,932–44,658,341, forward strandKRTAP12-3KRTAP12-2: 44,666,189–44,666,927, reverse strandKRTAP12-2KRTAP12-1: 44,681,576–44,682,163, reverse strandKRTAP12-1KRTAP10-12: 44,697,172–44,698,044, forward strandKRTAP10-12UBE2G2: 44,768,580–44,801,826, reverse strandUBE2G2SUMO3: 44,805,604–44,818,779, reverse strandSUMO3PTTG1IP: 44,849,585–44,873,903, reverse strandPTTG1IPITGB2: 44,885,953–44,920,899, reverse strandITGB2SLX9: 44,939,938–44,977,014, forward strandSLX9ADARB1: 45,073,839–45,226,560, forward strandADARB1POFUT2: 45,263,019–45,287,898, reverse strandPOFUT2Diagram of ITGB2: 16 exons on the reverse strand of chromosome 21Exon 15: 1 known disease-causing siteExon 14: 6 known disease-causing sitesExon 13: 5 known disease-causing sitesExon 12: 4 known disease-causing sitesExon 11: 4 known disease-causing sitesExon 10: 3 known disease-causing sitesExon 9: 3 known disease-causing sitesExon 8: 2 known disease-causing sitesExon 7: 7 known disease-causing sitesExon 6: 4 known disease-causing sitesExon 5: 4 known disease-causing sitesExon 4: 4 known disease-causing sitesExon 3: 2 known disease-causing sitesExon 2: 1 known disease-causing siteExon 16: 44,885,953–44,886,430, 478 basesExon 15: 44,886,736–44,886,902, 167 basesExon 14: 44,888,693–44,888,895, 203 basesExon 13: 44,889,276–44,889,495, 220 basesExon 12: 44,889,978–44,890,222, 245 basesExon 11: 44,891,809–44,891,996, 188 basesExon 10: 44,893,404–44,893,544, 141 basesExon 9: 44,894,971–44,895,060, 90 basesExon 8: 44,899,067–44,899,162, 96 basesExon 7: 44,900,320–44,900,475, 156 basesExon 6: 44,901,492–44,901,733, 242 basesExon 5: 44,903,365–44,903,535, 171 basesExon 4: 44,906,915–44,907,095, 181 basesExon 3: 44,910,284–44,910,372, 89 basesExon 2: 44,910,725–44,910,785, 61 basesExon 1: 44,920,821–44,920,899, 79 bases16141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.8 kb of the gene's 34.9 kb; 2,310 of those bases code for the protein.

How a genome test reads ITGB2

60

positions in ITGB2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 34.9 kb of ITGB2, introns included, not only the 2.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ITGB2 gene: integrin subunit beta 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/itgb2

Vancouver

Dante Labs. ITGB2 gene: integrin subunit beta 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/itgb2

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