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Gene

AGR2

anterior gradient 2, protein disulphide isomerase family member

Summary

Cytogenetic location
7p21.1
Coordinates
Chromosome 7: 16,791,811–16,804,999 (GRCh38)
Exons
8 exons across 13.2 kb
Protein
175 amino acids
Also known as
XAG-2, HAG-2, AG2, PDIA17
MANE Select transcript
ENST00000419304.7NM_006408.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads AGR2 yet. The test sequences your whole genome, so your data includes it all the same.

How AGR2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 7, with a bracket where AGR2 sits. AGR2 and 8 genes near it on chromosome 7, from 16,298,405 to 17,298,404.Chromosome 77p21.1p22.3p22.2p22.1p21.3p21.2p21.1p15.3p15.2p15.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.21q11.22q11.23q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q31.1q31.2q31.31q31.32q31.33q32.1q32.2q32.3q33q34q35q36.1q36.2q36.316.4 Mb16.6 Mb16.8 Mb17 Mb17.2 MbCRPPA: 16,087,525–16,502,504, reverse strandCRPPASOSTDC1: 16,460,622–16,530,580, reverse strandSOSTDC1LRRC72: 16,526,825–16,581,568, forward strandLRRC72ANKMY2: 16,599,779–16,645,841, reverse strandANKMY2BZW2: 16,644,653–16,706,771, forward strandBZW2TSPAN13: 16,753,727–16,784,652, forward strandTSPAN13AGR2: 16,791,811–16,804,999, reverse strandAGR2AGR3: 16,854,680–16,881,990, reverse strandAGR3AHR: 16,916,359–17,346,152, forward strandAHRDiagram of AGR2: 8 exons on the reverse strand of chromosome 7Exon 6: 1 known disease-causing siteExon 4: 2 known disease-causing sitesExon 2: 1 known disease-causing siteExon 8: 16,791,811–16,792,957, 1,147 basesExon 7: 16,794,936–16,795,019, 84 basesExon 6: 16,797,631–16,797,694, 64 basesExon 5: 16,799,744–16,799,817, 74 basesExon 4: 16,801,151–16,801,203, 53 basesExon 3: 16,801,320–16,801,383, 64 basesExon 2: 16,801,658–16,801,803, 146 basesExon 1: 16,804,935–16,804,999, 65 bases864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.7 kb of the gene's 13.2 kb; 528 of those bases code for the protein.

How a genome test reads AGR2

5

positions in AGR2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 13.2 kb of AGR2, introns included, not only the 1.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). AGR2 gene: anterior gradient 2, protein disulphide isomerase family member. Retrieved 17 October 2026, from https://dantelabs.com/genes/agr2

Vancouver

Dante Labs. AGR2 gene: anterior gradient 2, protein disulphide isomerase family member [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/agr2

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