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Gene

ANKRD26

ankyrin repeat domain 26

Summary

Cytogenetic location
10p12.1
Coordinates
Chromosome 10: 27,004,116–27,100,494 (GRCh38)
Exons
34 exons across 96.4 kb
Protein
1,710 amino acids
Also known as
KIAA1074
Previous symbols
THC2
MANE Select transcript
ENST00000376087.5NM_014915.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Inherited Thrombocytopenias

    • Inherited Thrombocytopenia

      A group of conditions causing a lifelong low platelet count, linked to genes such as MYH9, ANKRD26, ETV6, WAS, MPL, RBM8A, GATA1 and MECOM, and inherited in dominant, recessive or X-linked patterns.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      A genetic diagnosis avoids misdiagnosis as immune thrombocytopenia, with unnecessary steroids or spleen removal, and guides monitoring for related kidney, hearing or blood problems.

How ANKRD26 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 10, with a bracket where ANKRD26 sits. ANKRD26 and 8 genes near it on chromosome 10, from 26,552,305 to 27,552,304.Chromosome 1010p12.1p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.326.6 Mb26.8 Mb27 Mb27.2 Mb27.4 MbAPBB1IP: 26,438,160–26,568,449, forward strandAPBB1IPPDSS1: 26,697,441–26,746,798, forward strandPDSS1ABI1: 26,745,266–26,861,094, reverse strandABI1ANKRD26: 27,004,116–27,100,494, reverse strandANKRD26YME1L1: 27,107,777–27,155,266, reverse strandYME1L1MASTL: 27,154,425–27,187,953, forward strandMASTLACBD5: 27,168,135–27,243,046, reverse strandACBD5PTCHD3: 27,397,121–27,414,368, reverse strandPTCHD3RAB18: 27,504,174–27,545,117, forward strandRAB18Diagram of ANKRD26: 34 exons on the reverse strand of chromosome 10Exon 22: 1 known disease-causing siteExon 21: 1 known disease-causing siteExon 1: 8 known disease-causing sitesExon 34: 27,004,116–27,005,723, 1,608 basesExon 33: 27,006,917–27,006,962, 46 basesExon 32: 27,012,882–27,013,110, 229 basesExon 31: 27,014,494–27,014,711, 218 basesExon 30: 27,017,502–27,017,792, 291 basesExon 29: 27,022,558–27,022,687, 130 basesExon 28: 27,024,447–27,024,559, 113 basesExon 27: 27,028,852–27,028,945, 94 basesExon 26: 27,029,286–27,029,356, 71 basesExon 25: 27,033,225–27,033,377, 153 basesExon 24: 27,034,796–27,035,752, 957 basesExon 23: 27,037,186–27,037,323, 138 basesExon 22: 27,037,871–27,038,054, 184 basesExon 21: 27,039,965–27,040,178, 214 basesExon 20: 27,043,426–27,043,567, 142 basesExon 19: 27,044,157–27,044,190, 34 basesExon 18: 27,046,353–27,046,523, 171 basesExon 17: 27,048,801–27,048,979, 179 basesExon 16: 27,053,320–27,053,390, 71 basesExon 15: 27,060,345–27,060,417, 73 basesExon 14: 27,060,512–27,060,540, 29 basesExon 13: 27,061,144–27,061,242, 99 basesExon 12: 27,063,988–27,064,081, 94 basesExon 11: 27,066,487–27,066,548, 62 basesExon 10: 27,067,157–27,067,286, 130 basesExon 9: 27,077,338–27,077,540, 203 basesExon 8: 27,077,633–27,077,693, 61 basesExon 7: 27,079,089–27,079,161, 73 basesExon 6: 27,082,803–27,082,833, 31 basesExon 5: 27,086,539–27,086,609, 71 basesExon 4: 27,092,406–27,092,512, 107 basesExon 3: 27,093,349–27,093,522, 174 basesExon 2: 27,093,685–27,093,799, 115 basesExon 1: 27,100,085–27,100,494, 410 bases343025201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.8 kb of the gene's 96.4 kb; 5,133 of those bases code for the protein.

How a genome test reads ANKRD26

10

positions in ANKRD26 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 96.4 kb of ANKRD26, introns included, not only the 6.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ANKRD26 gene: ankyrin repeat domain 26. Retrieved 16 October 2026, from https://dantelabs.com/genes/ankrd26

Vancouver

Dante Labs. ANKRD26 gene: ankyrin repeat domain 26 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/ankrd26

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