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Gene

RAB7A

RAB7A, member RAS oncogene family

Summary

Cytogenetic location
3q21.3
Coordinates
Chromosome 3: 128,726,183–128,814,798 (GRCh38)
Exons
6 exons across 88.6 kb
Protein
207 amino acids
Previous symbols
RAB7, CMT2B
MANE Select transcript
ENST00000265062.8NM_004637.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Charcot-Marie-Tooth Disease

      • One of 62 genes linked to it

        A group of inherited peripheral neuropathies causing progressive weakness and wasting of the distal muscles and loss of sensation, mainly in the feet and hands.

        • ClinGen rates the link definitive
        • 3 GenCC submitters rate it definitive or strong
        What knowing changes

        Genetic counseling, subtype-specific monitoring, physical therapy, orthotics, neurotoxic drug avoidance, gene-specific clinical trials, surveillance for associated features

    How RAB7A is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 3, with a bracket where RAB7A sits. RAB7A and 13 genes near it on chromosome 3, from 128,270,491 to 129,270,490.Chromosome 33q21.3p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q29128.4 Mb128.6 Mb128.8 Mb129 Mb129.2 MbEEFSEC: 128,153,174–128,427,044, forward strandEEFSECDNAJB8: 128,462,437–128,466,968, reverse strandDNAJB8GATA2: 128,479,423–128,493,208, reverse strandGATA2RPN1: 128,619,968–128,681,075, reverse strandRPN1RAB7A: 128,726,183–128,814,798, forward strandRAB7AACAD9: 128,879,494–128,924,003, forward strandACAD9CFAP92: 128,909,866–129,002,690, reverse strandCFAP92EFCC1: 129,001,302–129,040,742, forward strandEFCC1GP9: 129,060,774–129,062,435, forward strandGP9RAB43: 129,087,569–129,123,694, reverse strandRAB43ISY1-RAB43: 129,087,575–129,161,036, reverse strandISY1-RAB43ISY1: 129,127,415–129,161,349, reverse strandISY1CNBP: 129,167,291–129,184,008, reverse strandCNBPCOPG1: 129,249,575–129,278,068, forward strandCOPG1Diagram of RAB7A: 6 exons on the forward strand of chromosome 3Exon 4: 1 known disease-causing siteExon 5: 4 known disease-causing sitesExon 1: 128,726,183–128,726,359, 177 basesExon 2: 128,795,360–128,795,420, 61 basesExon 3: 128,797,943–128,798,069, 127 basesExon 4: 128,806,372–128,806,590, 219 basesExon 5: 128,807,543–128,807,671, 129 basesExon 6: 128,813,327–128,814,798, 1,472 bases12465′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 2.2 kb of the gene's 88.6 kb; 624 of those bases code for the protein.

    How a genome test reads RAB7A

    5

    positions in RAB7A where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 88.6 kb of RAB7A, introns included, not only the 2.2 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). RAB7A gene: RAB7A, member RAS oncogene family. Retrieved 16 October 2026, from https://dantelabs.com/genes/rab7a

    Vancouver

    Dante Labs. RAB7A gene: RAB7A, member RAS oncogene family [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/rab7a

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