Skip to content
Use your HSA or FSA funds

Gene

FBXO38

F-box protein 38

Summary

Cytogenetic location
5q32
Coordinates
Chromosome 5: 148,383,958–148,442,836 (GRCh38)
Exons
22 exons across 58.9 kb
Protein
1,188 amino acids
Also known as
MOKA, SP329, FLJ13962, Fbx38
MANE Select transcript
ENST00000340253.10NM_205836.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Charcot-Marie-Tooth Disease

    • Distal Hereditary Motor Neuropathy

      Inherited neuropathies that mainly affect motor nerves, causing weakness and wasting of the hands and feet, including SORD-related neuropathy.

      • ClinGen rates the link moderate
      • 1 GenCC submitter rates it definitive or strong

  • Spinal Muscular Atrophy

    • A group of disorders characterised by degeneration of spinal cord anterior horn cells, leading to progressive muscle weakness and atrophy.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Gene therapy (onasemnogene abeparvovec), antisense oligonucleotide therapy (nusinersen), oral splicing modifier (risdiplam), supportive care

How FBXO38 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 5, with a bracket where FBXO38 sits. FBXO38 and 9 genes near it on chromosome 5, from 147,913,397 to 148,913,396.Chromosome 55q32p15.33p15.32p15.31p15.2p15.1p14.3p14.2p14.1p13.3p13.2p13.1p12p11q11.1q11.2q12.1q12.2q12.3q13.1q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q31.1q31.2q31.3q32q33.1q33.2q33.3q34q35.1q35.2q35.3148 Mb148.2 Mb148.4 Mb148.6 Mb148.8 MbSPINK5: 148,025,683–148,141,031, forward strandSPINK5SPINK14: 148,168,546–148,175,619, forward strandSPINK14SPINK6: 148,202,794–148,215,137, forward strandSPINK6MARCOL: 148,221,650–148,243,580, forward strandMARCOLSPINK13: 148,268,180–148,286,255, forward strandSPINK13SPINK7: 148,312,419–148,315,924, forward strandSPINK7SPINK9: 148,321,203–148,339,852, forward strandSPINK9FBXO38: 148,383,958–148,442,836, forward strandFBXO38HTR4: 148,446,042–148,677,235, reverse strandHTR4ADRB2: 148,826,611–148,828,623, forward strandADRB2Diagram of FBXO38: 22 exons on the forward strand of chromosome 5Exon 6: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 1: 148,383,958–148,384,039, 82 basesExon 2: 148,394,714–148,394,904, 191 basesExon 3: 148,398,999–148,399,132, 134 basesExon 4: 148,401,982–148,402,145, 164 basesExon 5: 148,402,348–148,402,513, 166 basesExon 6: 148,404,685–148,404,822, 138 basesExon 7: 148,406,257–148,406,394, 138 basesExon 8: 148,409,124–148,409,217, 94 basesExon 9: 148,410,635–148,410,765, 131 basesExon 10: 148,414,136–148,414,306, 171 basesExon 11: 148,415,928–148,416,070, 143 basesExon 12: 148,416,994–148,417,204, 211 basesExon 13: 148,423,998–148,424,117, 120 basesExon 14: 148,425,522–148,425,701, 180 basesExon 15: 148,427,213–148,427,947, 735 basesExon 16: 148,433,424–148,433,524, 101 basesExon 17: 148,433,635–148,433,737, 103 basesExon 18: 148,438,332–148,438,498, 167 basesExon 19: 148,439,647–148,439,792, 146 basesExon 20: 148,440,424–148,440,527, 104 basesExon 21: 148,441,124–148,441,237, 114 basesExon 22: 148,441,969–148,442,836, 868 bases12468101214161820225′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.4 kb of the gene's 58.9 kb; 3,567 of those bases code for the protein.

How a genome test reads FBXO38

2

positions in FBXO38 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 58.9 kb of FBXO38, introns included, not only the 4.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). FBXO38 gene: F-box protein 38. Retrieved 17 October 2026, from https://dantelabs.com/genes/fbxo38

Vancouver

Dante Labs. FBXO38 gene: F-box protein 38 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/fbxo38

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test