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Gene

DDX11

DEAD/H-box helicase 11

Summary

Cytogenetic location
12p11.21
Coordinates
Chromosome 12: 31,073,860–31,104,799 (GRCh38)
Exons
27 exons across 30.9 kb
Protein
906 amino acids
Also known as
ChlR1, KRG-2, CHL1, WABS
MANE Select transcript
ENST00000542838.6NM_030653.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads DDX11 yet. The test sequences your whole genome, so your data includes it all the same.

How DDX11 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 12, with a bracket where DDX11 sits. DDX11 and 5 genes near it on chromosome 12, from 30,589,330 to 31,589,329.Chromosome 1212p11.21p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3330.6 Mb30.8 Mb31 Mb31.2 Mb31.4 MbIPO8: 30,628,981–30,695,908, reverse strandIPO8CAPRIN2: 30,709,508–30,823,302, reverse strandCAPRIN2TSPAN11: 30,926,428–30,996,602, forward strandTSPAN11DDX11: 31,073,860–31,104,799, forward strandDDX11SINHCAF: 31,280,423–31,327,058, reverse strandSINHCAFDENND5B: 31,377,500–31,591,201, reverse strandDENND5BDiagram of DDX11: 27 exons on the forward strand of chromosome 12Exon 3: 1 known disease-causing siteExon 4: 3 known disease-causing sitesExon 7: 2 known disease-causing sitesExon 8: 1 known disease-causing siteExon 9: 2 known disease-causing sitesExon 10: 1 known disease-causing siteExon 11: 1 known disease-causing siteExon 13: 3 known disease-causing sitesExon 16: 1 known disease-causing siteExon 17: 1 known disease-causing siteExon 18: 1 known disease-causing siteExon 19: 1 known disease-causing siteExon 20: 2 known disease-causing sitesExon 22: 2 known disease-causing sitesExon 23: 1 known disease-causing siteExon 24: 1 known disease-causing siteExon 26: 1 known disease-causing siteExon 1: 31,073,860–31,074,091, 232 basesExon 2: 31,078,390–31,078,537, 148 basesExon 3: 31,083,813–31,084,061, 249 basesExon 4: 31,084,583–31,084,669, 87 basesExon 5: 31,084,969–31,085,126, 158 basesExon 6: 31,087,938–31,087,983, 46 basesExon 7: 31,089,044–31,089,151, 108 basesExon 8: 31,089,403–31,089,490, 88 basesExon 9: 31,089,886–31,090,094, 209 basesExon 10: 31,091,719–31,091,871, 153 basesExon 11: 31,092,846–31,092,892, 47 basesExon 12: 31,093,245–31,093,324, 80 basesExon 13: 31,094,590–31,094,634, 45 basesExon 14: 31,094,755–31,094,822, 68 basesExon 15: 31,096,341–31,096,379, 39 basesExon 16: 31,096,637–31,096,745, 109 basesExon 17: 31,096,859–31,096,990, 132 basesExon 18: 31,097,885–31,097,997, 113 basesExon 19: 31,100,635–31,100,707, 73 basesExon 20: 31,101,027–31,101,130, 104 basesExon 21: 31,101,833–31,101,982, 150 basesExon 22: 31,102,243–31,102,311, 69 basesExon 23: 31,102,427–31,102,527, 101 basesExon 24: 31,102,936–31,103,020, 85 basesExon 25: 31,103,317–31,103,395, 79 basesExon 26: 31,103,577–31,103,731, 155 basesExon 27: 31,103,807–31,104,799, 993 bases1510152025275′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.9 kb of the gene's 30.9 kb; 2,721 of those bases code for the protein.

How a genome test reads DDX11

41

positions in DDX11 where ClinVar classes a change as pathogenic or likely pathogenic

41 of them (100%) fall in regions short reads find hard.

  • Low mappability (31 sites)Regions where 100 bp or 250 bp reads cannot be placed uniquely.
  • Segmental duplications (41 sites)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

A whole genome covers all 30.9 kb of DDX11, introns included, not only the 3.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DDX11 gene: DEAD/H-box helicase 11. Retrieved 16 October 2026, from https://dantelabs.com/genes/ddx11

Vancouver

Dante Labs. DDX11 gene: DEAD/H-box helicase 11 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/ddx11

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