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Gene

POU3F3

POU class 3 homeobox 3

Summary

Cytogenetic location
2q12.1
Coordinates
Chromosome 2: 104,854,115–104,858,574 (GRCh38)
Exons
1 exon across 4.5 kb
Protein
500 amino acids
Also known as
BRN1, OTF8
MANE Select transcript
ENST00000361360.4NM_006236.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads POU3F3 yet. The test sequences your whole genome, so your data includes it all the same.

How POU3F3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 2, with a bracket where POU3F3 sits. POU3F3 and 5 genes near it on chromosome 2, from 104,356,345 to 105,356,344.Chromosome 22q12.1p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.3104.4 Mb104.6 Mb104.8 Mb105 Mb105.2 MbPOU3F3: 104,854,115–104,858,574, forward strandPOU3F3MRPS9: 105,037,968–105,099,960, forward strandMRPS9GPR45: 105,241,743–105,243,467, forward strandGPR45TGFBRAP1: 105,264,287–105,330,049, reverse strandTGFBRAP1TSLIG2: 105,337,516–105,360,776, forward strandTSLIG2FHL2: 105,352,159–105,438,585, reverse strandFHL2Diagram of POU3F3: one exon on the forward strand of chromosome 2Exon 1: 26 known disease-causing sitesExon 1: 104,854,115–104,858,574, 4,460 bases15′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.5 kb of the gene's 4.5 kb; 1,503 of those bases code for the protein.

How a genome test reads POU3F3

26

positions in POU3F3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 4.5 kb of POU3F3, introns included, not only the 4.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). POU3F3 gene: POU class 3 homeobox 3. Retrieved 16 October 2026, from https://dantelabs.com/genes/pou3f3

Vancouver

Dante Labs. POU3F3 gene: POU class 3 homeobox 3 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/pou3f3

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