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Gene

CNOT2

CCR4-NOT transcription complex subunit 2

Summary

Cytogenetic location
12q15
Coordinates
Chromosome 12: 70,243,433–70,354,993 (GRCh38)
Exons
16 exons across 111.6 kb
Protein
540 amino acids
Also known as
CDC36, NOT2H
Previous symbols
NOT2
MANE Select transcript
ENST00000229195.8NM_014515.7
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads CNOT2 yet. The test sequences your whole genome, so your data includes it all the same.

How CNOT2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 12, with a bracket where CNOT2 sits. CNOT2 and 6 genes near it on chromosome 12, from 69,799,213 to 70,799,212.Chromosome 1212q15p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3369.8 Mb70 Mb70.2 Mb70.4 Mb70.6 MbRAB3IP: 69,738,785–69,823,204, forward strandRAB3IP: 69,801,669–69,855,363, forward strandMYRFL: 69,825,222–69,959,097, forward strandMYRFLCNOT2: 70,243,433–70,354,993, forward strandCNOT2KCNMB4: 70,366,204–70,434,292, forward strandKCNMB4PTPRB: 70,515,870–70,637,440, reverse strandPTPRBPTPRR: 70,638,067–70,920,842, reverse strandPTPRRDiagram of CNOT2: 16 exons on the forward strand of chromosome 12Exon 11: 1 known disease-causing siteExon 14: 1 known disease-causing siteExon 16: 1 known disease-causing siteExon 1: 70,243,433–70,243,480, 48 basesExon 2: 70,278,132–70,278,274, 143 basesExon 3: 70,310,895–70,311,017, 123 basesExon 4: 70,319,298–70,319,364, 67 basesExon 5: 70,329,423–70,329,570, 148 basesExon 6: 70,330,287–70,330,469, 183 basesExon 7: 70,332,767–70,332,846, 80 basesExon 8: 70,335,438–70,335,563, 126 basesExon 9: 70,337,389–70,337,513, 125 basesExon 10: 70,338,443–70,338,563, 121 basesExon 11: 70,338,666–70,338,822, 157 basesExon 12: 70,342,107–70,342,168, 62 basesExon 13: 70,342,258–70,342,307, 50 basesExon 14: 70,344,128–70,344,228, 101 basesExon 15: 70,346,180–70,346,324, 145 basesExon 16: 70,353,829–70,354,993, 1,165 bases151015165′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.8 kb of the gene's 111.6 kb; 1,623 of those bases code for the protein.

How a genome test reads CNOT2

3

positions in CNOT2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 111.6 kb of CNOT2, introns included, not only the 2.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CNOT2 gene: CCR4-NOT transcription complex subunit 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/cnot2

Vancouver

Dante Labs. CNOT2 gene: CCR4-NOT transcription complex subunit 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/cnot2

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