Gene
TRA2B
transformer 2 beta homolog
- HGNC 10781↗(opens in a new tab)
- Ensembl gene ENSG00000136527↗(opens in a new tab)
- NCBI Gene 6434↗(opens in a new tab)
Summary
- Cytogenetic location
- 3q27.2
- Coordinates
- Chromosome 3: 185,914,558–185,938,014 (GRCh38)
- Exons
- 9 exons across 23.5 kb
- Protein
- 288 amino acids
- Also known as
- Htra2-beta, PPP1R156
- Previous symbols
- SFRS10
- MANE Select transcript
- ENST00000453386.7NM_004593.3
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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How TRA2B is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 4.2 kb of the gene's 23.5 kb; 867 of those bases code for the protein.
Traits linked to TRA2B
The Human Phenotype Ontology lists these as features of the rare conditions TRA2B can cause. Each trait's page lists the other genes linked to it.
Abnormality of the nervous system
- Delayed ability to walk
- Delayed speech and language development
- Difficulty staying asleep
- Inability to coordinate movements when walking
- Intellectual disability
- Moderate global developmental delay
- Profound global developmental delay
- Severe global developmental delay
Show 15 more traits
- Difficulty sleeping
- Generalized brain degeneration
- Hypsarrhythmia
- Infantile spasms
- Interictal EEG abnormality
- Thin corpus callosum
- Ventriculomegaly
- Aggressive behavior
- Autism spectrum disorder
- Cortical dysplasia
- Delayed CNS myelination
- Epileptic encephalopathy
- Low frustration tolerance
- Repetitive movements
- Small cerebellum
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
Cite this page
Dante Labs. (n.d.). TRA2B gene: transformer 2 beta homolog. Retrieved 16 October 2026, from https://dantelabs.com/genes/tra2b
Dante Labs. TRA2B gene: transformer 2 beta homolog [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/tra2b
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