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Gene

RBPJ

recombination signal binding protein for immunoglobulin kappa J region

Summary

Cytogenetic location
4p15.2
Coordinates
Chromosome 4: 26,321,014–26,434,923 (GRCh38)
Exons
11 exons across 113.9 kb
Protein
487 amino acids
Also known as
SUH, IGKJRB, RBPJK, KBF2, RBP-J, CBF1
Previous symbols
IGKJRB1, RBPSUH
MANE Select transcript
ENST00000355476.8NM_015874.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads RBPJ yet. The test sequences your whole genome, so your data includes it all the same.

How RBPJ is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 4, with a bracket where RBPJ sits. RBPJ and 4 genes near it on chromosome 4, from 25,877,969 to 26,877,968.Chromosome 44p15.2p16.3p16.2p16.1p15.33p15.32p15.31p15.2p15.1p14p13p12p11q11q12q13.1q13.2q13.3q21.1q21.21q21.22q21.23q21.3q22.1q22.2q22.3q23q24q25q26q27q28.1q28.2q28.3q31.1q31.21q31.22q31.23q31.3q32.1q32.2q32.3q33q34.1q34.2q34.3q35.1q35.226 Mb26.2 Mb26.4 Mb26.6 Mb26.8 MbSMIM20: 25,861,830–25,931,807, forward strandSMIM20RBPJ: 26,321,014–26,434,923, forward strandRBPJCCKAR: 26,481,396–26,490,484, reverse strandCCKARTBC1D19: 26,576,437–26,761,664, forward strandTBC1D19STIM2: 26,857,601–27,026,269, forward strandSTIM2Diagram of RBPJ: 11 exons on the forward strand of chromosome 4Exon 3: 2 known disease-causing sitesExon 4: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 1: 26,321,014–26,321,048, 35 basesExon 2: 26,386,353–26,386,391, 39 basesExon 3: 26,406,175–26,406,270, 96 basesExon 4: 26,415,475–26,415,640, 166 basesExon 5: 26,420,551–26,420,725, 175 basesExon 6: 26,424,342–26,424,479, 138 basesExon 7: 26,424,631–26,424,743, 113 basesExon 8: 26,428,720–26,428,860, 141 basesExon 9: 26,429,898–26,430,053, 156 basesExon 10: 26,430,419–26,430,522, 104 basesExon 11: 26,430,692–26,434,923, 4,232 bases1115′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.4 kb of the gene's 113.9 kb; 1,464 of those bases code for the protein.

How a genome test reads RBPJ

4

positions in RBPJ where ClinVar classes a change as pathogenic or likely pathogenic

1 of them (25%) falls in a region short reads find hard.

  • Segmental duplications (1 site)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

A whole genome covers all 113.9 kb of RBPJ, introns included, not only the 5.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). RBPJ gene: recombination signal binding protein for immunoglobulin kappa J region. Retrieved 16 October 2026, from https://dantelabs.com/genes/rbpj

Vancouver

Dante Labs. RBPJ gene: recombination signal binding protein for immunoglobulin kappa J region [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/rbpj

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