Trait
Metopic synostosis
Premature fusion of the metopic suture.
Summary
- Also called
- Metopic craniosynostosis, Metopic suture craniosynostosis
Reference genomeGRCh38hg38
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Get my Genome Test28 genes linked to Metopic synostosis
Changes in these genes cause rare conditions in which Metopic synostosis is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ASXL3ASXL transcriptional regulator 3 | Always | In 1 condition |
| FGFR1fibroblast growth factor receptor 1 | Always | In 2 conditions |
| GON4Lgon-4 like | Always | In 1 condition |
| GPC3glypican 3 | Always | In 1 condition |
| IL11RAinterleukin 11 receptor subunit alpha | Always | In 1 condition |
| NFIAnuclear factor I A | Always | In 1 condition |
| PPFIBP1PPFIB scaffold protein 1 | Always | In 1 condition |
| UBAP2Lubiquitin associated protein 2 like | Always | In 1 condition |
| FREM1FRAS1 related extracellular matrix 1 | Very often (80–99%) | In 2 conditions |
| PTCH1patched 1 | Very often (80–99%) | In 1 condition |
| PIGAphosphatidylinositol glycan anchor biosynthesis class A | Often (30–79%) | In 1 condition |
| PIGTphosphatidylinositol glycan anchor biosynthesis class T | Often (30–79%) | In 1 condition |
| SIX2SIX homeobox 2 | Often (30–79%) | In 1 condition |
| CDK8cyclin dependent kinase 8 | Sometimes (5–29%) | In 1 condition |
| DDB1damage specific DNA binding protein 1 | Sometimes (5–29%) | In 1 condition |
| DIAPH1diaphanous related formin 1 | Sometimes (5–29%) | In 1 condition |
| ERFETS2 repressor factor | Sometimes (5–29%) | In 1 condition |
| FBXO11F-box protein 11 | Sometimes (5–29%) | In 1 condition |
| GLI3GLI family zinc finger 3 | Sometimes (5–29%) | In 1 condition |
| HERC1HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | Sometimes (5–29%) | In 1 condition |
| HNRNPKheterogeneous nuclear ribonucleoprotein K | Sometimes (5–29%) | In 2 conditions |
| MSX2msh homeobox 2 | Sometimes (5–29%) | In 1 condition |
| OTUD5OTU deubiquitinase 5 | Sometimes (5–29%) | In 1 condition |
| PCDHGC4protocadherin gamma subfamily C, 4 | Sometimes (5–29%) | In 1 condition |
| POLR1ARNA polymerase I subunit A | Sometimes (5–29%) | In 1 condition |
| SONSON DNA and RNA binding protein | Sometimes (5–29%) | In 1 condition |
| TMEM216transmembrane protein 216 | Sometimes (5–29%) | In 1 condition |
| WDR35WD repeat domain 35 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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