Trait
Decreased parathyroid hormone secretion
Clinical name: Hypoparathyroidism
A condition caused by a deficiency of parathyroid hormone characterized by hypocalcemia and hyperphosphatemia.
Summary
- Also called
- Low parathyroid hormone
- Body system
- Abnormality of the endocrine system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test50 genes linked to Decreased parathyroid hormone secretion
Changes in these genes cause rare conditions in which Decreased parathyroid hormone secretion is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| GATA3GATA binding protein 3 | Always | In 2 conditions |
| KDM6Alysine demethylase 6A | Always | In 1 condition |
| KMT2Dlysine methyltransferase 2D | Always | In 1 condition |
| PTHparathyroid hormone | Always | In 1 condition |
| AIREautoimmune regulator | Very often (80–99%) | In 2 conditions |
| TBCEtubulin folding cofactor E | Very often (80–99%) | In 2 conditions |
| ARVCFARVCF delta catenin family member | Often (30–79%) | In 1 condition |
| CHD7chromodomain helicase DNA binding protein 7 | Often (30–79%) | In 1 condition |
| COMTcatechol-O-methyltransferase | Often (30–79%) | In 1 condition |
| GP1BBglycoprotein Ib platelet subunit beta | Often (30–79%) | In 1 condition |
| HIRAhistone cell cycle regulator | Often (30–79%) | In 1 condition |
| IRX5iroquois homeobox 5 | Often (30–79%) | In 1 condition |
| JMJD1Cjumonji domain containing 1C | Often (30–79%) | In 1 condition |
| RREB1ras responsive element binding protein 1 | Often (30–79%) | In 1 condition |
| SEC24CSEC24 homolog C, COPII component | Often (30–79%) | In 1 condition |
| TBX1T-box transcription factor 1 | Often (30–79%) | In 2 conditions |
| UFD1ubiquitin recognition factor in ER associated degradation 1 | Often (30–79%) | In 1 condition |
| ATP7BATPase copper transporting beta | Sometimes (5–29%) | In 2 conditions |
| DGCR2DiGeorge syndrome critical region gene 2 | Sometimes (5–29%) | In 1 condition |
| DGCR6DiGeorge syndrome critical region gene 6 | Sometimes (5–29%) | In 1 condition |
| DGCR8DGCR8 microprocessor complex subunit | Sometimes (5–29%) | In 1 condition |
| ESS2ess-2 spliceosome associated protein | Sometimes (5–29%) | In 1 condition |
| HADHAhydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha | Sometimes (5–29%) | In 1 condition |
| HADHBhydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta | Sometimes (5–29%) | In 1 condition |
| HBBhemoglobin subunit beta | Sometimes (5–29%) | In 3 conditions |
| MPV17mitochondrial inner membrane protein MPV17 | Sometimes (5–29%) | In 1 condition |
| MT-ATP8mitochondrially encoded ATP synthase membrane subunit 8 | Sometimes (5–29%) | In 1 condition |
| MT-TL1mitochondrially encoded tRNA-Leu (UUA/G) 1 | Sometimes (5–29%) | In 2 conditions |
| PIGTphosphatidylinositol glycan anchor biosynthesis class T | Sometimes (5–29%) | In 1 condition |
| RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2B | Sometimes (5–29%) | In 1 condition |
| TBX2T-box transcription factor 2 | Sometimes (5–29%) | In 1 condition |
| MT-CO1mitochondrially encoded cytochrome c oxidase I | Rarely (1–4%) | In 1 condition |
| MT-CO2mitochondrially encoded cytochrome c oxidase II | Rarely (1–4%) | In 1 condition |
| MT-CO3mitochondrially encoded cytochrome c oxidase III | Rarely (1–4%) | In 1 condition |
| MT-ND1mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 | Rarely (1–4%) | In 1 condition |
| MT-ND4mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 | Rarely (1–4%) | In 1 condition |
| MT-ND5mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 | Rarely (1–4%) | In 1 condition |
| MT-ND6mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 | Rarely (1–4%) | In 1 condition |
| MT-TFmitochondrially encoded tRNA-Phe (UUU/C) | Rarely (1–4%) | In 1 condition |
| MT-THmitochondrially encoded tRNA-His (CAU/C) | Rarely (1–4%) | In 1 condition |
Show 10 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| MT-TQmitochondrially encoded tRNA-Gln (CAA/G) | Rarely (1–4%) | In 1 condition |
| MT-TS1mitochondrially encoded tRNA-Ser (UCN) 1 | Rarely (1–4%) | In 1 condition |
| MT-TS2mitochondrially encoded tRNA-Ser (AGU/C) 2 | Rarely (1–4%) | In 1 condition |
| MT-TWmitochondrially encoded tRNA-Trp (UGA/G) | Rarely (1–4%) | In 1 condition |
| NKX2-1NK2 homeobox 1 | Rarely (1–4%) | In 1 condition |
| COL4A3collagen type IV alpha 3 chain | Not recorded | In 1 condition |
| COL4A4collagen type IV alpha 4 chain | Not recorded | In 1 condition |
| COL4A5collagen type IV alpha 5 chain | Not recorded | In 1 condition |
| FAM111AFAM111 trypsin like peptidase A | Not recorded | In 1 condition |
| PTH1Rparathyroid hormone 1 receptor | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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