Traits

Traits linked to HPGD

15-hydroxyprostaglandin dehydrogenase

The Human Phenotype Ontology links 84 traits to HPGD, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the musculoskeletal system

Trait	How often it is seen
Abnormal cortical bone morphology	Very often (80–99%)
Abnormal shape of end part of bone	Very often (80–99%)
Abnormality of connective tissue	Very often (80–99%)
Bone pain	Very often (80–99%)
Arthritis	Often (30–79%)
Breakdown of bone	Often (30–79%)
Degenerative joint disease	Often (30–79%)
Joint stiffness	Often (30–79%)
Limitation of joint mobility	Often (30–79%)
Periostosis	Often (30–79%)
Death of bone due to decreased blood supply	Sometimes (5–29%)
Osteoporosis	Sometimes (5–29%)
Scoliosis	Sometimes (5–29%)
Disease of the joints	Not recorded
Funnel chest	Not recorded
Long collarbone	Not recorded
Osteopenia	Not recorded

Abnormality of limbs

Trait	How often it is seen
Clubbing of fingers and toes	Always
Abnormality of the knee	Often (30–79%)
Abnormality of the shankbone	Often (30–79%)
Broad finger	Often (30–79%)
Broad fingertip	Often (30–79%)
Broad thumb	Often (30–79%)
Broad toe	Often (30–79%)
Clubbed toes	Often (30–79%)
Clubbing of fingers	Often (30–79%)
Atypical position of finger	Sometimes (5–29%)
Outward bow-leggedness	Sometimes (5–29%)
Small hand	Sometimes (5–29%)
Thickening of palms and soles	Sometimes (5–29%)
Breakdown of small bones of fingers	Not recorded
Thickening of the outer layer of the skin of the palms and soles	Not recorded

Abnormality of the integument

Trait	How often it is seen
Excessive sweating	Very often (80–99%)
Mottled skin coloring	Very often (80–99%)
Thickened skin	Very often (80–99%)
Abnormal fingernails	Often (30–79%)
Abnormal hair quantity	Often (30–79%)
Atypical nail growth	Often (30–79%)
Broad nail	Often (30–79%)
Increased nail curvature	Often (30–79%)
Thick nail	Often (30–79%)
Abnormal hair pattern	Sometimes (5–29%)
Poor fingernail formation	Sometimes (5–29%)
Skin cancer	Sometimes (5–29%)
Abnormality of the skin	Not recorded
Flushing	Not recorded
Loose redundant skin	Not recorded

Abnormality of head or neck

Trait	How often it is seen
Abnormality of the skull	Very often (80–99%)
Wide fontanelles	Very often (80–99%)
Coarse facial features	Often (30–79%)
Furrows in thickened skin on top of scalp	Often (30–79%)
High, narrow palate	Often (30–79%)
Long eyelashes	Often (30–79%)
Extra bones within cranial sutures	Not recorded
High palate	Not recorded
Increased thickness of skull cap	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Diarrhea	Often (30–79%)
Nausea	Often (30–79%)
Enlarged liver	Sometimes (5–29%)
Malabsorption	Sometimes (5–29%)
Sore in the lining of gastrointestinal tract	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
Bone infection	Very often (80–99%)
Seborrheic dermatitis	Very often (80–99%)
Acne	Often (30–79%)
Eczema	Sometimes (5–29%)
Unusual fungal nail infection	Sometimes (5–29%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Bone marrow disease	Sometimes (5–29%)
Gastrointestinal bleeding	Sometimes (5–29%)
Low number of red blood cells or hemoglobin	Sometimes (5–29%)
Myelofibrosis	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Increased spleen size	Sometimes (5–29%)
Patent ductus arteriosus	Not recorded
Redness of skin or mucous membrane	Not recorded

Abnormality of the endocrine system

Trait	How often it is seen
Decreased circulating insulin-like growth factor 1 concentration	Often (30–79%)
Growth hormone excess	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Cerebral palsy	Sometimes (5–29%)
Impaired temperature sensation	Sometimes (5–29%)

Laboratory abnormality

Trait	How often it is seen
Fluid retention	Often (30–79%)
Joint swelling	Often (30–79%)

Abnormality of the breast

Trait	How often it is seen
Enlarged male breast	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Drooping upper eyelid	Often (30–79%)

Abnormality of the respiratory system

Trait	How often it is seen
Lung cancer	Sometimes (5–29%)

Constitutional symptom

Trait	How often it is seen
Joint pain	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Disproportionate tall stature	Not recorded

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to HPGD and how often each is seen. Find out more at hpo.jax.org.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test