Trait
Slurred speech
Abnormal coordination of muscles involved in speech.
Summary
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test59 genes linked to Slurred speech
Changes in these genes cause rare conditions in which Slurred speech is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ITPR1inositol 1,4,5-trisphosphate receptor type 1 | Always | In 2 conditions |
| PAN2poly(A) specific ribonuclease subunit PAN2 | Always | In 1 condition |
| PDE8Bphosphodiesterase 8B | Always | In 1 condition |
| RAB3ARAB3A, member RAS oncogene family | Always | In 1 condition |
| SLC1A3solute carrier family 1 member 3 | Always | In 2 conditions |
| SLC2A1solute carrier family 2 member 1 | Always | In 1 condition |
| VPS13Cvacuolar protein sorting 13 homolog C | Always | In 1 condition |
| CACNA1Acalcium voltage-gated channel subunit alpha1 A | Very often (80–99%) | In 1 condition |
| MT-TKmitochondrially encoded tRNA-Lys (AAA/G) | Very often (80–99%) | In 1 condition |
| NEU1neuraminidase 1 | Very often (80–99%) | In 2 conditions |
| SPTBN2spectrin beta, non-erythrocytic 2 | Very often (80–99%) | In 2 conditions |
| ANO10anoctamin 10 | Often (30–79%) | In 1 condition |
| ATMATM serine/threonine kinase | Often (30–79%) | In 1 condition |
| ATP6AP2ATPase H+ transporting accessory protein 2 | Often (30–79%) | In 2 conditions |
| ATP6V0A2ATPase H+ transporting V0 subunit a2 | Often (30–79%) | In 1 condition |
| ATXN1ataxin 1 | Often (30–79%) | In 1 condition |
| CWF19L1CWF19 like cell cycle control factor 1 | Often (30–79%) | In 1 condition |
| DPP9dipeptidyl peptidase 9 | Often (30–79%) | In 1 condition |
| FASTKD2FASTK mitochondrial RNA regulator 2 | Often (30–79%) | In 1 condition |
| KCNA1potassium voltage-gated channel subfamily A member 1 | Often (30–79%) | In 2 conditions |
| LINGO1leucine rich repeat and Ig domain containing 1 | Often (30–79%) | In 1 condition |
| MYORGmyogenesis regulating glycosidase | Often (30–79%) | In 2 conditions |
| POLGDNA polymerase gamma, catalytic subunit | Often (30–79%) | In 1 condition |
| PRNPprion protein (Kanno blood group) | Often (30–79%) | In 2 conditions |
| SPARTspartin | Often (30–79%) | In 1 condition |
| SPG7SPG7 matrix AAA peptidase subunit, paraplegin | Often (30–79%) | In 1 condition |
| TBC1D2BTBC1 domain family member 2B | Often (30–79%) | In 1 condition |
| CHD8chromodomain helicase DNA binding protein 8 | Sometimes (5–29%) | In 1 condition |
| CMPK2cytidine/uridine monophosphate kinase 2 | Sometimes (5–29%) | In 1 condition |
| CTSHcathepsin H | Sometimes (5–29%) | In 1 condition |
| GALCgalactosylceramidase | Sometimes (5–29%) | In 1 condition |
| GRIN2Aglutamate ionotropic receptor NMDA type subunit 2A | Sometimes (5–29%) | In 1 condition |
| HCRThypocretin neuropeptide precursor | Sometimes (5–29%) | In 1 condition |
| HLA-DQB1major histocompatibility complex, class II, DQ beta 1 | Sometimes (5–29%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Sometimes (5–29%) | In 1 condition |
| JAM2junctional adhesion molecule 2 | Sometimes (5–29%) | In 1 condition |
| KCND3potassium voltage-gated channel subfamily D member 3 | Sometimes (5–29%) | In 1 condition |
| KCNQ2potassium voltage-gated channel subfamily Q member 2 | Sometimes (5–29%) | In 1 condition |
| MAB21L1mab-21 like 1 | Sometimes (5–29%) | In 1 condition |
| MOGmyelin oligodendrocyte glycoprotein | Sometimes (5–29%) | In 1 condition |
Show 19 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| NAA60N-alpha-acetyltransferase 60, NatF catalytic subunit | Sometimes (5–29%) | In 1 condition |
| P2RY11purinergic receptor P2Y11 | Sometimes (5–29%) | In 1 condition |
| PDGFBplatelet derived growth factor subunit B | Sometimes (5–29%) | In 1 condition |
| PDGFRBplatelet derived growth factor receptor beta | Sometimes (5–29%) | In 1 condition |
| RRP12ribosomal RNA processing 12 homolog | Sometimes (5–29%) | In 1 condition |
| SCN2Asodium voltage-gated channel alpha subunit 2 | Sometimes (5–29%) | In 1 condition |
| SLC20A2solute carrier family 20 member 2 | Sometimes (5–29%) | In 1 condition |
| SUPT16HSPT16 homolog, facilitates chromatin remodeling subunit | Sometimes (5–29%) | In 1 condition |
| TNFSF4TNF superfamily member 4 | Sometimes (5–29%) | In 1 condition |
| TRANK1tetratricopeptide repeat and ankyrin repeat containing 1 | Sometimes (5–29%) | In 1 condition |
| VPS13Avacuolar protein sorting 13 homolog A | Sometimes (5–29%) | In 1 condition |
| XPR1xenotropic and polytropic retrovirus receptor 1 | Sometimes (5–29%) | In 1 condition |
| ZNF365zinc finger protein 365 | Sometimes (5–29%) | In 1 condition |
| DARS2aspartyl-tRNA synthetase 2, mitochondrial | Rarely (1–4%) | In 1 condition |
| ABCD1ATP binding cassette subfamily D member 1 | Not recorded | In 1 condition |
| CA8carbonic anhydrase 8 (inactive) | Not recorded | In 1 condition |
| EZH2enhancer of zeste 2 polycomb repressive complex 2 subunit | Not recorded | In 1 condition |
| GLB1galactosidase beta 1 | Not recorded | In 1 condition |
| SETD2SET domain containing 2, histone lysine methyltransferase | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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