Trait
Diffuse cerebral atrophy
Diffuse unlocalised atrophy affecting the cerebrum.
Summary
- Also called
- Cerebral atrophy, diffuse
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
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Get my Genome Test59 genes linked to Diffuse cerebral atrophy
Changes in these genes cause rare conditions in which Diffuse cerebral atrophy is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| APTXaprataxin | Always | In 1 condition |
| COG2component of oligomeric golgi complex 2 | Always | In 2 conditions |
| COQ2coenzyme Q2, polyprenyltransferase | Always | In 1 condition |
| CTSFcathepsin F | Always | In 1 condition |
| DNM1Ldynamin 1L | Always | In 2 conditions |
| FARS2phenylalanyl-tRNA synthetase 2, mitochondrial | Always | In 1 condition |
| FDXRferredoxin reductase | Always | In 2 conditions |
| MED17mediator complex subunit 17 | Always | In 1 condition |
| MOCS2molybdenum cofactor synthesis 2 | Always | In 1 condition |
| WARS2tryptophanyl tRNA synthetase 2, mitochondrial | Always | In 1 condition |
| ATP13A2ATPase cation transporting 13A2 | Often (30–79%) | In 1 condition |
| CARS2cysteinyl-tRNA synthetase 2, mitochondrial | Often (30–79%) | In 1 condition |
| DNM1dynamin 1 | Often (30–79%) | In 1 condition |
| ERCC6ERCC excision repair 6, chromatin remodeling factor | Often (30–79%) | In 1 condition |
| GLB1galactosidase beta 1 | Often (30–79%) | In 2 conditions |
| KARS1lysyl-tRNA synthetase 1 | Often (30–79%) | In 1 condition |
| PMPCApeptidase, mitochondrial processing subunit alpha | Often (30–79%) | In 1 condition |
| PRKAR1Bprotein kinase cAMP-dependent type I regulatory subunit beta | Often (30–79%) | In 1 condition |
| TIAM1TIAM Rac1 associated GEF 1 | Often (30–79%) | In 1 condition |
| UQCRC1ubiquinol-cytochrome c reductase core protein 1 | Often (30–79%) | In 1 condition |
| ARXaristaless related homeobox | Sometimes (5–29%) | In 1 condition |
| ATP6AP2ATPase H+ transporting accessory protein 2 | Sometimes (5–29%) | In 1 condition |
| CACNA1Ecalcium voltage-gated channel subunit alpha1 E | Sometimes (5–29%) | In 1 condition |
| CASKcalcium/calmodulin dependent serine protein kinase | Sometimes (5–29%) | In 1 condition |
| CDKL5cyclin dependent kinase like 5 | Sometimes (5–29%) | In 1 condition |
| COG5component of oligomeric golgi complex 5 | Sometimes (5–29%) | In 1 condition |
| DCDC2doublecortin domain containing 2 | Sometimes (5–29%) | In 1 condition |
| DMXL2Dmx like 2 | Sometimes (5–29%) | In 1 condition |
| GALCgalactosylceramidase | Sometimes (5–29%) | In 2 conditions |
| GNAO1G protein subunit alpha o1 | Sometimes (5–29%) | In 1 condition |
| GRIN1glutamate ionotropic receptor NMDA type subunit 1 | Sometimes (5–29%) | In 1 condition |
| GRIN2Aglutamate ionotropic receptor NMDA type subunit 2A | Sometimes (5–29%) | In 1 condition |
| GRM7glutamate metabotropic receptor 7 | Sometimes (5–29%) | In 1 condition |
| HSD17B10hydroxysteroid 17-beta dehydrogenase 10 | Sometimes (5–29%) | In 1 condition |
| HTRA1HtrA serine peptidase 1 | Sometimes (5–29%) | In 1 condition |
| JKAMPJNK1/MAPK8 associated membrane protein | Sometimes (5–29%) | In 1 condition |
| KCNA1potassium voltage-gated channel subfamily A member 1 | Sometimes (5–29%) | In 1 condition |
| LGI1leucine rich glioma inactivated 1 | Sometimes (5–29%) | In 1 condition |
| NEUROD2neuronal differentiation 2 | Sometimes (5–29%) | In 1 condition |
| PIGPphosphatidylinositol glycan anchor biosynthesis class P | Sometimes (5–29%) | In 1 condition |
Show 19 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| PIGQphosphatidylinositol glycan anchor biosynthesis class Q | Sometimes (5–29%) | In 1 condition |
| PNKPpolynucleotide kinase 3'-phosphatase | Sometimes (5–29%) | In 1 condition |
| PSAPprosaposin | Sometimes (5–29%) | In 1 condition |
| RARS1arginyl-tRNA synthetase 1 | Sometimes (5–29%) | In 1 condition |
| RHOBTB2Rho related BTB domain containing 2 | Sometimes (5–29%) | In 1 condition |
| SCN1Bsodium voltage-gated channel beta subunit 1 | Sometimes (5–29%) | In 1 condition |
| SCN2Asodium voltage-gated channel alpha subunit 2 | Sometimes (5–29%) | In 1 condition |
| SIK1salt inducible kinase 1 | Sometimes (5–29%) | In 1 condition |
| SLC25A22solute carrier family 25 member 22 | Sometimes (5–29%) | In 1 condition |
| SLC32A1solute carrier family 32 member 1 | Sometimes (5–29%) | In 1 condition |
| TBC1D24TBC1 domain family member 24 | Sometimes (5–29%) | In 1 condition |
| TMEM67transmembrane protein 67 | Sometimes (5–29%) | In 1 condition |
| TRIM8tripartite motif containing 8 | Sometimes (5–29%) | In 1 condition |
| VPS16VPS16 core subunit of CORVET and HOPS complexes | Sometimes (5–29%) | In 1 condition |
| DHCR77-dehydrocholesterol reductase | Rarely (1–4%) | In 1 condition |
| BTDbiotinidase | Not recorded | In 1 condition |
| FMR1fragile X messenger ribonucleoprotein 1 | Not recorded | In 1 condition |
| TBCDtubulin folding cofactor D | Not recorded | In 1 condition |
| TBPTATA-box binding protein | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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