Trait
Hyperactive movements
Clinical name: Hyperkinetic movements
Motor hyperactivity with excessive movement of muscles of the body as a whole.
Summary
- Also called
- Hyperkinesia, Hyperkinesis
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
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Get my Genome Test45 genes linked to Hyperactive movements
Changes in these genes cause rare conditions in which Hyperactive movements is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| FBXL4F-box and leucine rich repeat protein 4 | Always | In 1 condition |
| NEUROG1neurogenin 1 | Always | In 1 condition |
| OPA1OPA1 mitochondrial dynamin like GTPase | Always | In 1 condition |
| PSAPprosaposin | Always | In 1 condition |
| SCN2Asodium voltage-gated channel alpha subunit 2 | Always | In 1 condition |
| SUCLA2succinate-CoA ligase ADP-forming subunit beta | Always | In 1 condition |
| WARS2tryptophanyl tRNA synthetase 2, mitochondrial | Always | In 1 condition |
| GNEglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | Very often (80–99%) | In 1 condition |
| NGLY1N-glycanase 1 | Very often (80–99%) | In 2 conditions |
| LETM1leucine zipper and EF-hand containing transmembrane protein 1 | Often (30–79%) | In 1 condition |
| MTRR5-methyltetrahydrofolate-homocysteine methyltransferase reductase | Often (30–79%) | In 1 condition |
| NEUROD2neuronal differentiation 2 | Often (30–79%) | In 1 condition |
| PNKDPNKD metallo-beta-lactamase domain containing | Often (30–79%) | In 1 condition |
| PRRT2proline rich transmembrane protein 2 | Often (30–79%) | In 1 condition |
| RRAGDRas related GTP binding D | Often (30–79%) | In 1 condition |
| SCN1Asodium voltage-gated channel alpha subunit 1 | Often (30–79%) | In 1 condition |
| SLC6A3solute carrier family 6 member 3 | Often (30–79%) | In 1 condition |
| SLC9A6solute carrier family 9 member A6 | Often (30–79%) | In 2 conditions |
| SYT1synaptotagmin 1 | Often (30–79%) | In 2 conditions |
| TRAPPC11trafficking protein particle complex subunit 11 | Often (30–79%) | In 2 conditions |
| BCKDKbranched chain keto acid dehydrogenase kinase | Sometimes (5–29%) | In 1 condition |
| CAMK2Bcalcium/calmodulin dependent protein kinase II beta | Sometimes (5–29%) | In 1 condition |
| CLPBClpB family mitochondrial disaggregase | Sometimes (5–29%) | In 1 condition |
| GAD1glutamate decarboxylase 1 | Sometimes (5–29%) | In 1 condition |
| GRIN2Aglutamate ionotropic receptor NMDA type subunit 2A | Sometimes (5–29%) | In 1 condition |
| HSD17B10hydroxysteroid 17-beta dehydrogenase 10 | Sometimes (5–29%) | In 1 condition |
| IARS2isoleucyl-tRNA synthetase 2, mitochondrial | Sometimes (5–29%) | In 1 condition |
| IQSEC2IQ motif and Sec7 domain ArfGEF 2 | Sometimes (5–29%) | In 1 condition |
| PTS6-pyruvoyltetrahydropterin synthase | Sometimes (5–29%) | In 1 condition |
| RTTNrotatin | Sometimes (5–29%) | In 1 condition |
| SUCLG1succinate-CoA ligase GDP/ADP-forming subunit alpha | Sometimes (5–29%) | In 1 condition |
| THOC2THO complex subunit 2 | Sometimes (5–29%) | In 2 conditions |
| VPS13Avacuolar protein sorting 13 homolog A | Sometimes (5–29%) | In 1 condition |
| YME1L1YME1 like 1 ATPase | Sometimes (5–29%) | In 1 condition |
| AFG3L2AFG3 like matrix AAA peptidase subunit 2 | Rarely (1–4%) | In 1 condition |
| ALDH5A1aldehyde dehydrogenase 5 family member A1 | Not recorded | In 1 condition |
| CACNA1Bcalcium voltage-gated channel subunit alpha1 B | Not recorded | In 1 condition |
| CACNA1Ecalcium voltage-gated channel subunit alpha1 E | Not recorded | In 1 condition |
| FRRS1Lferric chelate reductase 1 like | Not recorded | In 1 condition |
| GCH1GTP cyclohydrolase 1 | Not recorded | In 1 condition |
Show 5 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| GNAO1G protein subunit alpha o1 | Not recorded | In 1 condition |
| GRIN1glutamate ionotropic receptor NMDA type subunit 1 | Not recorded | In 1 condition |
| PDE10Aphosphodiesterase 10A | Not recorded | In 1 condition |
| PYCR2pyrroline-5-carboxylate reductase 2 | Not recorded | In 1 condition |
| ZNF142zinc finger protein 142 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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