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Gene

LRTOMT

leucine rich transmembrane and O-methyltransferase domain containing

Summary

Cytogenetic location
11q13.4
Also known as
COMT2, CFAP111, LRTOMT1, LRTOMT2
Previous symbols
LRRC51, DFNB63
Locus type
readthrough

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Hearing Loss and Deafness

      • Nonsyndromic Genetic Hearing Loss

        One of 97 genes linked to it

        Inherited hearing loss without other medical features, including the common recessive forms caused by GJB2, OTOF, SLC26A4, STRC and many other genes, as well as dominant, X-linked and mitochondrial forms.

        • ClinGen rates the link definitive
        • 3 GenCC submitters rate it definitive or strong
        What knowing changes

        Knowing the genetic cause can guide hearing support and cochlear implant decisions, gene-therapy trial eligibility (for example OTOF) and family counselling.

    How a genome test reads LRTOMT

    18

    positions in LRTOMT where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). LRTOMT gene: leucine rich transmembrane and O-methyltransferase domain containing. Retrieved 17 October 2026, from https://dantelabs.com/genes/lrtomt

    Vancouver

    Dante Labs. LRTOMT gene: leucine rich transmembrane and O-methyltransferase domain containing [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/lrtomt

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