Trait

Prolonged prothrombin time

Increased time to coagulation in the prothrombin time test, which is a measure of the extrinsic pathway of coagulation. The results of the prothrombin time test are often expressed in terms of the International normalized ratio (INR), which is calculated as a ratio of the patient's prothrombin time (PT) to a control PT standardized for the potency of the thromboplastin reagent developed by the World Health Organization (WHO) using the formula: INR is equal to Patient PT divided by Control PT.

HPO HP:0008151

Also called: Increased INR, Increased international normalised ratio, Increased international normalized ratio, Low factor II activity, Prolonged PT, Reduced factor II activity, Reduced prothrombin activity
Body system: Abnormality of blood and blood-forming tissues

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53 genes linked to Prolonged prothrombin time

Changes in these genes cause rare conditions in which Prolonged prothrombin time is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
AMACRalpha-methylacyl-CoA racemase	Always	In 1 condition
CYP7B1cytochrome P450 family 7 subfamily B member 1	Always	In 1 condition
EFL1elongation factor like GTPase 1	Always	In 1 condition
F10coagulation factor X	Always	In 2 conditions
GGCXgamma-glutamyl carboxylase	Always	In 3 conditions
MICOS13mitochondrial contact site and cristae organizing system subunit 13	Always	In 1 condition
NR1H4nuclear receptor subfamily 1 group H member 4	Always	In 1 condition
PET100PET100 cytochrome c oxidase chaperone	Always	In 1 condition
PSMB9proteasome 20S subunit beta 9	Always	In 1 condition
RINT1RAD50 interactor 1	Always	In 1 condition
RNU6ATACRNA, U6atac small nuclear	Always	In 1 condition
SLC37A4solute carrier family 37 member 4	Always	In 1 condition
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2	Always	In 1 condition
TRMUtRNA mitochondrial 2-thiouridylase	Always	In 1 condition
ADKadenosine kinase	Very often (80–99%)	In 1 condition
F2coagulation factor II, thrombin	Very often (80–99%)	In 2 conditions
GNEglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Very often (80–99%)	In 1 condition
LMAN1lectin, mannose binding 1	Very often (80–99%)	In 1 condition
MCFD2multiple coagulation factor deficiency 2, ER cargo receptor complex subunit	Very often (80–99%)	In 1 condition
MPV17mitochondrial inner membrane protein MPV17	Very often (80–99%)	In 1 condition
SLC25A13solute carrier family 25 member 13	Very often (80–99%)	In 1 condition
ACAD9acyl-CoA dehydrogenase family member 9	Often (30–79%)	In 1 condition
AHCYadenosylhomocysteinase	Often (30–79%)	In 1 condition
AKR1D1aldo-keto reductase family 1 member D1	Often (30–79%)	In 1 condition
ALG12ALG12 alpha-1,6-mannosyltransferase	Often (30–79%)	In 1 condition
ANO6anoctamin 6	Often (30–79%)	In 1 condition
CD46CD46 molecule	Often (30–79%)	In 1 condition
CFHcomplement factor H	Often (30–79%)	In 1 condition
CFIcomplement factor I	Often (30–79%)	In 1 condition
F7coagulation factor VII	Often (30–79%)	In 1 condition
HELLPARHELLP associated long non-coding RNA	Often (30–79%)	In 1 condition
HMGCL3-hydroxy-3-methylglutaryl-CoA lyase	Often (30–79%)	In 1 condition
PGM1phosphoglucomutase 1	Often (30–79%)	In 1 condition
VKORC1vitamin K epoxide reductase complex subunit 1	Often (30–79%)	In 1 condition
CLPBClpB family mitochondrial disaggregase	Sometimes (5–29%)	In 1 condition
COG8component of oligomeric golgi complex 8	Sometimes (5–29%)	In 1 condition
F8coagulation factor VIII	Sometimes (5–29%)	In 1 condition
GPR35G protein-coupled receptor 35	Sometimes (5–29%)	In 1 condition
HADHhydroxyacyl-CoA dehydrogenase	Sometimes (5–29%)	In 1 condition
MST1macrophage stimulating 1	Sometimes (5–29%)	In 1 condition

Show 13 more genes

Gene	How often it is seen	Conditions
MTTPmicrosomal triglyceride transfer protein	Sometimes (5–29%)	In 1 condition
NGLY1N-glycanase 1	Sometimes (5–29%)	In 1 condition
OTCornithine transcarbamylase	Sometimes (5–29%)	In 1 condition
SEMA4Dsemaphorin 4D	Sometimes (5–29%)	In 1 condition
SLC30A10solute carrier family 30 member 10	Sometimes (5–29%)	In 1 condition
TCF4transcription factor 4	Sometimes (5–29%)	In 1 condition
F5coagulation factor V	Not recorded	In 1 condition
FAHfumarylacetoacetate hydrolase	Not recorded	In 1 condition
HLA-DQA1major histocompatibility complex, class II, DQ alpha 1	Not recorded	In 1 condition
HLA-DQB1major histocompatibility complex, class II, DQ beta 1	Not recorded	In 1 condition
NBASNBAS subunit of NRZ tethering complex	Not recorded	In 1 condition
PMM2phosphomannomutase 2	Not recorded	In 1 condition
PRF1perforin 1	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal prothrombin time

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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