Trait
Increased CSF lactate
Increased concentration of lactate in the cerebrospinal fluid.
Summary
- Also called
- Hyperlactatorachia, Increased cerebrospinal fluid lactate, Increased CSF lactic acid
Reference genomeGRCh38hg38
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Read the genes linked to Increased CSF lactate, and the rest of your genome, with one test.
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Get my Genome Test127 genes linked to Increased CSF lactate
Changes in these genes cause rare conditions in which Increased CSF lactate is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AIFM1apoptosis inducing factor mitochondria associated 1 | Always | In 2 conditions |
| ATP5POATP synthase peripheral stalk subunit OSCP | Always | In 1 condition |
| ATPAF2ATP synthase mitochondrial F1 complex assembly factor 2 | Always | In 1 condition |
| CLPBClpB family mitochondrial disaggregase | Always | In 1 condition |
| COX10cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 | Always | In 2 conditions |
| COX14cytochrome c oxidase assembly factor COX14 | Always | In 1 condition |
| COX20cytochrome c oxidase assembly factor COX20 | Always | In 1 condition |
| COX4I1cytochrome c oxidase subunit 4I1 | Always | In 1 condition |
| COX8Acytochrome c oxidase subunit 8A | Always | In 1 condition |
| COXFA4cytochrome c oxidase associated subunit FA4 | Always | In 1 condition |
| ECHS1enoyl-CoA hydratase, short chain 1 | Always | In 1 condition |
| FASTKD5FASTK mitochondrial RNA regulator 5 | Always | In 1 condition |
| FDXRferredoxin reductase | Always | In 1 condition |
| IBA57iron-sulfur cluster assembly factor IBA57 | Always | In 2 conditions |
| LRPPRCleucine rich pentatricopeptide repeat containing | Always | In 2 conditions |
| LYRM7LYR motif containing 7 | Always | In 1 condition |
| MDH2malate dehydrogenase 2 | Always | In 1 condition |
| MPV17mitochondrial inner membrane protein MPV17 | Always | In 2 conditions |
| MTFMTmitochondrial methionyl-tRNA formyltransferase | Always | In 1 condition |
| NADK2NAD kinase 2, mitochondrial | Always | In 1 condition |
| NAXENAD(P)HX epimerase | Always | In 2 conditions |
| NDUFA10NADH:ubiquinone oxidoreductase subunit A10 | Always | In 1 condition |
| NDUFA12NADH:ubiquinone oxidoreductase subunit A12 | Always | In 1 condition |
| NDUFA8NADH:ubiquinone oxidoreductase subunit A8 | Always | In 1 condition |
| NDUFAF2NADH:ubiquinone oxidoreductase complex assembly factor 2 | Always | In 2 conditions |
| NDUFAF3NADH:ubiquinone oxidoreductase complex assembly factor 3 | Always | In 2 conditions |
| NDUFAF5NADH:ubiquinone oxidoreductase complex assembly factor 5 | Always | In 2 conditions |
| NDUFB8NADH:ubiquinone oxidoreductase subunit B8 | Always | In 1 condition |
| NDUFS1NADH:ubiquinone oxidoreductase core subunit S1 | Always | In 2 conditions |
| NDUFS3NADH:ubiquinone oxidoreductase core subunit S3 | Always | In 2 conditions |
| NDUFS4NADH:ubiquinone oxidoreductase subunit S4 | Always | In 2 conditions |
| NDUFV1NADH:ubiquinone oxidoreductase core subunit V1 | Always | In 2 conditions |
| NFU1NFU1 iron-sulfur cluster scaffold | Always | In 2 conditions |
| NUBPLNUBP iron-sulfur cluster assembly factor, mitochondrial | Always | In 2 conditions |
| OPA1OPA1 mitochondrial dynamin like GTPase | Always | In 2 conditions |
| PDHA1pyruvate dehydrogenase E1 subunit alpha 1 | Always | In 2 conditions |
| PET100PET100 cytochrome c oxidase chaperone | Always | In 1 condition |
| PET117PET117 cytochrome c oxidase chaperone | Always | In 1 condition |
| PNPT1polyribonucleotide nucleotidyltransferase 1 | Always | In 2 conditions |
| SCO2synthesis of cytochrome C oxidase 2 | Always | In 2 conditions |
Show 87 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| SLC25A19solute carrier family 25 member 19 | Always | In 1 condition |
| SLC25A4solute carrier family 25 member 4 | Always | In 2 conditions |
| SLC31A1solute carrier family 31 member 1 | Always | In 1 condition |
| SUCLA2succinate-CoA ligase ADP-forming subunit beta | Always | In 1 condition |
| SUCLG1succinate-CoA ligase GDP/ADP-forming subunit alpha | Always | In 2 conditions |
| TIMM50translocase of inner mitochondrial membrane 50 | Always | In 1 condition |
| TRMT10CtRNA methyltransferase 10C, mitochondrial RNase P subunit | Always | In 1 condition |
| UQCC2ubiquinol-cytochrome c reductase complex assembly factor 2 | Always | In 1 condition |
| UQCC3ubiquinol-cytochrome c reductase complex assembly factor 3 | Always | In 1 condition |
| FOXRED1FAD dependent oxidoreductase domain containing 1 | Very often (80–99%) | In 1 condition |
| HSD17B10hydroxysteroid 17-beta dehydrogenase 10 | Very often (80–99%) | In 1 condition |
| IARS2isoleucyl-tRNA synthetase 2, mitochondrial | Very often (80–99%) | In 1 condition |
| LONP1lon peptidase 1, mitochondrial | Very often (80–99%) | In 1 condition |
| MT-ATP6mitochondrially encoded ATP synthase membrane subunit 6 | Very often (80–99%) | In 1 condition |
| MT-ND1mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 | Very often (80–99%) | In 3 conditions |
| MT-ND2mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 | Very often (80–99%) | In 2 conditions |
| MT-ND3mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3 | Very often (80–99%) | In 2 conditions |
| MT-ND4mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 | Very often (80–99%) | In 2 conditions |
| MT-ND5mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 | Very often (80–99%) | In 2 conditions |
| MT-ND6mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 | Very often (80–99%) | In 2 conditions |
| MT-TKmitochondrially encoded tRNA-Lys (AAA/G) | Very often (80–99%) | In 1 condition |
| MT-TL1mitochondrially encoded tRNA-Leu (UUA/G) 1 | Very often (80–99%) | In 3 conditions |
| MT-TVmitochondrially encoded tRNA-Val (GUN) | Very often (80–99%) | In 1 condition |
| MT-TWmitochondrially encoded tRNA-Trp (UGA/G) | Very often (80–99%) | In 2 conditions |
| NDUFA1NADH:ubiquinone oxidoreductase subunit A1 | Very often (80–99%) | In 1 condition |
| NDUFA11NADH:ubiquinone oxidoreductase subunit A11 | Very often (80–99%) | In 1 condition |
| NDUFA6NADH:ubiquinone oxidoreductase subunit A6 | Very often (80–99%) | In 2 conditions |
| NDUFA9NADH:ubiquinone oxidoreductase subunit A9 | Very often (80–99%) | In 1 condition |
| NDUFAF1NADH:ubiquinone oxidoreductase complex assembly factor 1 | Very often (80–99%) | In 1 condition |
| NDUFAF4NADH:ubiquinone oxidoreductase complex assembly factor 4 | Very often (80–99%) | In 1 condition |
| NDUFAF8NADH:ubiquinone oxidoreductase complex assembly factor 8 | Very often (80–99%) | In 1 condition |
| NDUFB10NADH:ubiquinone oxidoreductase subunit B10 | Very often (80–99%) | In 1 condition |
| NDUFB11NADH:ubiquinone oxidoreductase subunit B11 | Very often (80–99%) | In 1 condition |
| NDUFB3NADH:ubiquinone oxidoreductase subunit B3 | Very often (80–99%) | In 1 condition |
| NDUFB9NADH:ubiquinone oxidoreductase subunit B9 | Very often (80–99%) | In 1 condition |
| NDUFS2NADH:ubiquinone oxidoreductase core subunit S2 | Very often (80–99%) | In 1 condition |
| NDUFS6NADH:ubiquinone oxidoreductase subunit S6 | Very often (80–99%) | In 1 condition |
| NDUFS7NADH:ubiquinone oxidoreductase core subunit S7 | Very often (80–99%) | In 1 condition |
| NDUFS8NADH:ubiquinone oxidoreductase core subunit S8 | Very often (80–99%) | In 1 condition |
| NDUFV2NADH:ubiquinone oxidoreductase core subunit V2 | Very often (80–99%) | In 1 condition |
| PDHXpyruvate dehydrogenase complex component X | Very often (80–99%) | In 1 condition |
| TIMMDC1translocase of inner mitochondrial membrane domain containing 1 | Very often (80–99%) | In 1 condition |
| TMEM126Btransmembrane protein 126B | Very often (80–99%) | In 1 condition |
| TXN2thioredoxin 2 | Very often (80–99%) | In 2 conditions |
| COA8cytochrome c oxidase assembly factor 8 | Often (30–79%) | In 1 condition |
| COQ8Acoenzyme Q8A | Often (30–79%) | In 2 conditions |
| COX11cytochrome c oxidase copper chaperone COX11 | Often (30–79%) | In 1 condition |
| DNM1Ldynamin 1L | Often (30–79%) | In 1 condition |
| FARS2phenylalanyl-tRNA synthetase 2, mitochondrial | Often (30–79%) | In 1 condition |
| GFM2GTP dependent ribosome recycling factor mitochondrial 2 | Often (30–79%) | In 2 conditions |
| HMBShydroxymethylbilane synthase | Often (30–79%) | In 1 condition |
| HPDL4-hydroxyphenylpyruvate dioxygenase like | Often (30–79%) | In 1 condition |
| LYRM4LYR motif containing 4 | Often (30–79%) | In 1 condition |
| MRPS34mitochondrial ribosomal protein S34 | Often (30–79%) | In 1 condition |
| MT-CO1mitochondrially encoded cytochrome c oxidase I | Often (30–79%) | In 1 condition |
| MT-CO2mitochondrially encoded cytochrome c oxidase II | Often (30–79%) | In 1 condition |
| MT-CO3mitochondrially encoded cytochrome c oxidase III | Often (30–79%) | In 1 condition |
| MT-TFmitochondrially encoded tRNA-Phe (UUU/C) | Often (30–79%) | In 1 condition |
| MT-THmitochondrially encoded tRNA-His (CAU/C) | Often (30–79%) | In 1 condition |
| MT-TQmitochondrially encoded tRNA-Gln (CAA/G) | Often (30–79%) | In 1 condition |
| MT-TS1mitochondrially encoded tRNA-Ser (UCN) 1 | Often (30–79%) | In 2 conditions |
| MT-TS2mitochondrially encoded tRNA-Ser (AGU/C) 2 | Often (30–79%) | In 1 condition |
| NAXDNAD(P)HX dehydratase | Often (30–79%) | In 1 condition |
| RARS2arginyl-tRNA synthetase 2, mitochondrial | Often (30–79%) | In 1 condition |
| SLC13A3solute carrier family 13 member 3 | Often (30–79%) | In 1 condition |
| SLC2A1solute carrier family 2 member 1 | Often (30–79%) | In 1 condition |
| TPK1thiamin pyrophosphokinase 1 | Often (30–79%) | In 1 condition |
| ALDH4A1aldehyde dehydrogenase 4 family member A1 | Sometimes (5–29%) | In 1 condition |
| BOLA3bolA family member 3 | Sometimes (5–29%) | In 1 condition |
| DARS2aspartyl-tRNA synthetase 2, mitochondrial | Sometimes (5–29%) | In 1 condition |
| GLRX5glutaredoxin 5 | Sometimes (5–29%) | In 1 condition |
| ISCA2iron-sulfur cluster assembly 2 | Sometimes (5–29%) | In 1 condition |
| MECP2methyl-CpG binding protein 2 | Sometimes (5–29%) | In 1 condition |
| RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2B | Sometimes (5–29%) | In 1 condition |
| SLC39A8solute carrier family 39 member 8 | Sometimes (5–29%) | In 1 condition |
| TRAPPC12trafficking protein particle complex subunit 12 | Sometimes (5–29%) | In 1 condition |
| COX15cytochrome c oxidase assembly factor COX15 | Not recorded | In 1 condition |
| COX6B1cytochrome c oxidase subunit 6B1 | Not recorded | In 2 conditions |
| FASTKD2FASTK mitochondrial RNA regulator 2 | Not recorded | In 1 condition |
| GFM1G elongation factor mitochondrial 1 | Not recorded | In 1 condition |
| HTRA2HtrA serine peptidase 2 | Not recorded | In 1 condition |
| MT-TNmitochondrially encoded tRNA-Asn (AAU/C) | Not recorded | In 1 condition |
| NARS2asparaginyl-tRNA synthetase 2, mitochondrial | Not recorded | In 1 condition |
| RMND1required for meiotic nuclear division 1 homolog | Not recorded | In 1 condition |
| SCO1synthesis of cytochrome C oxidase 1 | Not recorded | In 1 condition |
| SURF1SURF1 cytochrome c oxidase assembly factor | Not recorded | In 1 condition |
| TACO1translational activator of cytochrome c oxidase I | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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