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Gene

VPS45

vacuolar protein sorting 45 homolog

Summary

Cytogenetic location
1q21.2
Coordinates
Chromosome 1: 150,067,776–150,145,329 (GRCh38)
Exons
15 exons across 77.6 kb
Protein
570 amino acids
Also known as
h-vps45, H1
Previous symbols
VPS45B, VPS45A
MANE Select transcript
ENST00000644510.2NM_007259.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

How VPS45 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where VPS45 sits. VPS45 and 31 genes near it on chromosome 1, from 149,606,553 to 150,606,552.Chromosome 11q21.2p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44149.8 Mb150 Mb150.2 Mb150.4 Mb150.6 MbFCGR1A: 149,734,951–149,792,526, forward strandFCGR1AH2BC18: 149,755,110–149,812,374, reverse strandH2BC18H3C13: 149,813,225–149,813,693, reverse strandH4C14: 149,832,657–149,839,767, forward strandH3C14: 149,840,687–149,841,208, reverse strandH3C14H2AC18: 149,842,218–149,842,750, reverse strandH2AC18H2AC19: 149,851,061–149,851,652, forward strandH3C15: 149,852,608–149,853,125, forward strandH3C15H4C15: 149,854,045–149,861,159, reverse strandH2BC21: 149,884,459–149,886,682, reverse strandBOLA1: 149,886,406–149,900,798, forward strandBOLA1H2AC20: 149,886,918–149,887,411, forward strandH2AC21: 149,887,469–149,887,965, reverse strandSV2A: 149,903,318–149,918,572, reverse strandSV2ASF3B4: 149,923,317–149,928,268, reverse strandSF3B4MTMR11: 149,928,650–149,937,534, reverse strandMTMR11OTUD7B: 149,937,812–150,010,758, reverse strandOTUD7BVPS45: 150,067,776–150,145,329, forward strandVPS45PLEKHO1: 150,149,183–150,164,720, forward strandPLEKHO1ANP32E: 150,217,463–150,236,202, reverse strandANP32ECA14: 150,257,069–150,265,078, forward strandCA14APH1A: 150,265,042–150,269,580, reverse strandAPH1AC1orf54: 150,268,034–150,281,744, forward strandC1orf54CIART: 150,282,527–150,287,093, forward strandCIARTMRPS21: 150,293,848–150,309,828, forward strandPRPF3: 150,321,476–150,353,341, forward strandPRPF3RPRD2: 150,363,091–150,476,999, forward strandRPRD2TARS2: 150,487,325–150,507,614, forward strandTARS2ECM1: 150,507,989–150,515,000, forward strandECM1ADAMTSL4: 150,549,369–150,560,937, forward strandADAMTSL4MCL1: 150,560,895–150,579,738, reverse strandMCL1ENSA: 150,599,671–150,629,633, reverse strandENSADiagram of VPS45: 15 exons on the forward strand of chromosome 1Exon 1: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 5: 2 known disease-causing sitesExon 7: 1 known disease-causing siteExon 8: 3 known disease-causing sitesExon 9: 1 known disease-causing siteExon 11: 3 known disease-causing sitesExon 12: 1 known disease-causing siteExon 13: 1 known disease-causing siteExon 1: 150,067,776–150,067,950, 175 basesExon 2: 150,068,630–150,068,764, 135 basesExon 3: 150,072,166–150,072,226, 61 basesExon 4: 150,076,233–150,076,312, 80 basesExon 5: 150,076,916–150,076,984, 69 basesExon 6: 150,077,094–150,077,231, 138 basesExon 7: 150,077,669–150,077,779, 111 basesExon 8: 150,081,342–150,081,476, 135 basesExon 9: 150,081,884–150,081,997, 114 basesExon 10: 150,082,716–150,082,883, 168 basesExon 11: 150,091,937–150,092,095, 159 basesExon 12: 150,092,302–150,092,409, 108 basesExon 13: 150,093,527–150,093,648, 122 basesExon 14: 150,110,496–150,110,627, 132 basesExon 15: 150,144,709–150,145,329, 621 bases1510155′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.3 kb of the gene's 77.6 kb; 1,713 of those bases code for the protein.

How a genome test reads VPS45

15

positions in VPS45 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 77.6 kb of VPS45, introns included, not only the 2.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). VPS45 gene: vacuolar protein sorting 45 homolog. Retrieved 16 October 2026, from https://dantelabs.com/genes/vps45

Vancouver

Dante Labs. VPS45 gene: vacuolar protein sorting 45 homolog [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/vps45

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