Traits

Traits linked to SDHB

succinate dehydrogenase complex iron sulfur subunit B

The Human Phenotype Ontology links 161 traits to SDHB, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	Hvor ofte det ses
Delayed ability to stand	Altid
Delayed ability to walk	Altid
Elevated brain lactate level by MRS	Altid
Falls	Altid
Hyperintensity of cerebral white matter on MRI	Altid
Increased reflexes	Altid
Irritability	Altid
Leukodystrophy	Altid
Loss of developmental milestones	Altid
Ataxia	Ofte (30–79 %)
Babinski sign	Ofte (30–79 %)
Brisk knee jerk	Ofte (30–79 %)
Cranial nerve paralysis	Ofte (30–79 %)
Dystonia	Ofte (30–79 %)
Episodic paroxysmal anxiety	Ofte (30–79 %)
Generalized myoclonic seizure	Ofte (30–79 %)
Hyperactive deep tendon reflexes	Ofte (30–79 %)
Motor delay	Ofte (30–79 %)
Progressive degeneration of movement	Ofte (30–79 %)
Progressive psychomotor deterioration	Ofte (30–79 %)
Recurrent paroxysmal headache	Ofte (30–79 %)
Upper limb hyperreflexia	Ofte (30–79 %)
Cancer of early nerve cells	Nogle gange (5–29 %)
Communication delay	Nogle gange (5–29 %)
Cranial nerve compression	Nogle gange (5–29 %)
Delayed ability to sit	Nogle gange (5–29 %)
Delayed speech and language development	Nogle gange (5–29 %)
Epilepsy	Nogle gange (5–29 %)
Febrile seizure (within the age range of 3 months to 6 years)	Nogle gange (5–29 %)
Focal myoclonic seizure	Nogle gange (5–29 %)
Headache	Nogle gange (5–29 %)
Inability to move vocal cords	Nogle gange (5–29 %)
Moderate global developmental delay	Nogle gange (5–29 %)
Panic attack	Nogle gange (5–29 %)
Tremor	Nogle gange (5–29 %)
Dementia	Sjældent (1–4%)
Loss of ability to walk	Sjældent (1–4%)

Abnormality of the cardiovascular system

Trait	Hvor ofte det ses
Abnormal left ventricular function	Ofte (30–79 %)
Abnormality of the cardiovascular system	Ofte (30–79 %)
Decrease in blood pressure upon standing up	Ofte (30–79 %)
Elevated heart rate	Ofte (30–79 %)
Enlarged and thickened heart muscle	Ofte (30–79 %)
Fainting spell	Ofte (30–79 %)
High blood pressure	Ofte (30–79 %)
Hypertension associated with pheochromocytoma	Ofte (30–79 %)
Hypertensive retinopathy	Ofte (30–79 %)
Left ventricular hypertrophy	Ofte (30–79 %)
Palpitations	Ofte (30–79 %)
Positive regitine blocking test	Ofte (30–79 %)
Sinus tachycardia	Ofte (30–79 %)
Swollen lymph nodes in center of chest	Ofte (30–79 %)
Abnormal atrioventricular conduction	Nogle gange (5–29 %)
Abnormal heart rate	Nogle gange (5–29 %)
Arachnoid hemangiomatosis	Nogle gange (5–29 %)
Cardiac failure	Nogle gange (5–29 %)
Disease of the heart muscle	Nogle gange (5–29 %)
Hypertensive crisis	Nogle gange (5–29 %)
Inflammation of heart muscle	Nogle gange (5–29 %)
Noncompaction cardiomyopathy	Nogle gange (5–29 %)
Swollen lymph nodes	Nogle gange (5–29 %)
Hives	Ikke registreret

Abnormality of the digestive system

Trait	Hvor ofte det ses
Feeding difficulties in infancy	Altid
Abdominal pain	Meget ofte (80–99 %)
Diarrhea	Meget ofte (80–99 %)
Gastrointestinal stroma tumor	Meget ofte (80–99 %)
Nausea and vomiting	Meget ofte (80–99 %)
Stomach tumor	Meget ofte (80–99 %)
Accumulation of fluid in the abdomen	Ofte (30–79 %)
Constipation	Ofte (30–79 %)
Intermittent abdominal pain	Ofte (30–79 %)
Intestinal obstruction	Ofte (30–79 %)
Nausea	Ofte (30–79 %)
Poor swallowing	Ofte (30–79 %)
Abdominal mass	Nogle gange (5–29 %)
Abnormality of the liver	Nogle gange (5–29 %)
Anorexia	Nogle gange (5–29 %)
Colon tumor	Nogle gange (5–29 %)
Esophageal tumor	Nogle gange (5–29 %)
Gastrointestinal tract tumor	Nogle gange (5–29 %)
Rectal tumor	Nogle gange (5–29 %)
Small intestine tumor	Nogle gange (5–29 %)

Abnormality of the musculoskeletal system

Trait	Hvor ofte det ses
Flexed joint that cannot be straightened	Altid
Generalized decreased muscle tone	Altid
Low muscle tone	Altid
Poor head control	Altid
Involuntary muscle stiffness, contraction, or spasm	Meget ofte (80–99 %)
Low muscle tone in trunk	Meget ofte (80–99 %)
Distal muscle wasting	Ofte (30–79 %)
Generalized muscle weakness	Ofte (30–79 %)
Proximal neurogenic muscle weakness	Ofte (30–79 %)
Skeletal myopathy	Ofte (30–79 %)
Tired easily	Ofte (30–79 %)
Frequent falls	Nogle gange (5–29 %)
Muscle degeneration	Nogle gange (5–29 %)
Spastic paraparesis	Nogle gange (5–29 %)
Spastic tetraparesis	Nogle gange (5–29 %)

Laboratory abnormality

Trait	Hvor ofte det ses
Higher than normal levels of lactate in blood	Altid
Increased circulating pyruvate concentration	Altid
Increased urine alpha-ketoglutarate concentration	Altid
Elevated urinary dopamine	Ofte (30–79 %)
Elevated urinary epinephrine level	Ofte (30–79 %)
Elevated urinary norepinephrine level	Ofte (30–79 %)
High blood calcium levels	Ofte (30–79 %)
High urine protein levels	Ofte (30–79 %)
Blood in urine	Nogle gange (5–29 %)
Elevated calcitonin	Nogle gange (5–29 %)
High blood sugar	Nogle gange (5–29 %)
Elevated urinary catecholamines	Ikke registreret

Abnormality of the endocrine system

Trait	Hvor ofte det ses
Adrenal pheochromocytoma	Meget ofte (80–99 %)
Extraadrenal pheochromocytoma	Meget ofte (80–99 %)
Paraganglioma	Meget ofte (80–99 %)
Pheochromocytoma	Meget ofte (80–99 %)
Adrenal overactivity	Ofte (30–79 %)
Adrenocortical adenoma	Ofte (30–79 %)
Paraganglioma of head and neck	Ofte (30–79 %)
Chemodectoma	Ikke registreret
Glomus jugular tumor	Ikke registreret

Abnormality of the eye

Trait	Hvor ofte det ses
Abnormality of the eye	Ofte (30–79 %)
Decreased clarity of vision	Ofte (30–79 %)
Absent iris	Sjældent (1–4%)
Blindness	Sjældent (1–4%)
Involuntary, rapid, rhythmic eye movements	Sjældent (1–4%)
Paralysis or weakness of muscles within or surrounding outer part of eye	Sjældent (1–4%)
Pigmentary retinopathy	Sjældent (1–4%)

Abnormality of the integument

Trait	Hvor ofte det ses
Flushing	Ofte (30–79 %)
Sporadic excessive sweating	Ofte (30–79 %)
Irregular hyperpigmentation	Nogle gange (5–29 %)
Paleness	Nogle gange (5–29 %)
Excessive sweating	Ikke registreret
Neurofibroma	Ikke registreret
Patchy darkened skin	Ikke registreret

Abnormality of the ear

Trait	Hvor ofte det ses
Hearing impairment	Ofte (30–79 %)
Paroxysmal vertigo	Ofte (30–79 %)
Pulsatile tinnitus	Ofte (30–79 %)
Ringing in ears	Ofte (30–79 %)
Conductive deafness	Nogle gange (5–29 %)

Abnormality of the genitourinary system

Trait	Hvor ofte det ses
Glomerular sclerosis	Ofte (30–79 %)
Cancer starting in small tubes in kidneys	Nogle gange (5–29 %)
Renal failure	Nogle gange (5–29 %)
Vesicoureteral reflux	Sjældent (1–4%)

Growth abnormality

Trait	Hvor ofte det ses
Proportionate short stature	Ofte (30–79 %)
Severe short stature	Ofte (30–79 %)
Weight loss	Ofte (30–79 %)
Prenatal growth deficiency	Nogle gange (5–29 %)

Abnormality of blood and blood-forming tissues

Trait	Hvor ofte det ses
Gastrointestinal bleeding	Meget ofte (80–99 %)
Bleeding in brain	Ofte (30–79 %)
Low number of red blood cells or hemoglobin	Nogle gange (5–29 %)

Abnormality of head or neck

Trait	Hvor ofte det ses
Abnormally small head	Nogle gange (5–29 %)
Mild microcephaly	Nogle gange (5–29 %)
Retinal capillary hemangioma	Nogle gange (5–29 %)

Abnormality of limbs

Trait	Hvor ofte det ses
Inability to straighten knee	Nogle gange (5–29 %)
Lower limb hypertonia	Nogle gange (5–29 %)
Large hands	Ikke registreret

Abnormal tissue mass

Trait	Hvor ofte det ses
Cancer of connective tissue	Meget ofte (80–99 %)
Leiomyosarcoma	Meget ofte (80–99 %)

Constitutional symptom

Trait	Hvor ofte det ses
Fatigue	Meget ofte (80–99 %)
Chest pain	Ofte (30–79 %)

Abnormal cellular phenotype

Trait	Hvor ofte det ses
Decreased activity of mitochondrial complex II	Altid

Abnormality of the immune system

Trait	Hvor ofte det ses
Skin rash	Nogle gange (5–29 %)

Abnormality of the respiratory system

Trait	Hvor ofte det ses
Lung infiltrates	Ofte (30–79 %)

Abnormality of the voice

Trait	Hvor ofte det ses
Inability to produce voice sounds	Ofte (30–79 %)

Hvor hyppigt det ses hos personer med en af genets tilstande, den hyppigste værdi på tværs af dem, sådan som Human Phenotype Ontology registrerer det. Disse sider beskriver egenskaber og den forskning, der ligger bag dem. De er ikke en diagnose, og hvis du har spørgsmål om symptomer, bør du spørge en læge eller genetisk rådgiver.

Hvor oplysningerne kommer fra

The Human Phenotype Ontology, release 2026-09-01: the traits linked to SDHB and how often each is seen. Find out more at hpo.jax.org.

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