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Gene

LAMB1

laminin subunit beta 1

Summary

Cytogenetic location
7q31.1
Coordinates
Chromosome 7: 107,923,799–108,003,161 (GRCh38)
Exons
34 exons across 79.4 kb
Protein
1,786 amino acids
Previous symbols
CLM
MANE Select transcript
ENST00000222399.11NM_002291.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads LAMB1 yet. The test sequences your whole genome, so your data includes it all the same.

How LAMB1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 7, with a bracket where LAMB1 sits. LAMB1 and 11 genes near it on chromosome 7, from 107,463,480 to 108,463,479.Chromosome 77q31.1p22.3p22.2p22.1p21.3p21.2p21.1p15.3p15.2p15.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.21q11.22q11.23q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q31.1q31.2q31.31q31.32q31.33q32.1q32.2q32.3q33q34q35q36.1q36.2q36.3107.6 Mb107.8 Mb108 Mb108.2 Mb108.4 MbCOG5: 107,198,800–107,564,515, reverse strandCOG5GPR22: 107,470,018–107,478,011, forward strandGPR22DUS4L: 107,563,484–107,579,483, forward strandDUS4LDUS4L-BCAP29: 107,563,971–107,623,317, forward strandDUS4L-BCAP29BCAP29: 107,579,957–107,633,139, forward strandBCAP29SLC26A4: 107,660,594–107,717,809, forward strandSLC26A4CBLL1: 107,743,073–107,762,079, forward strandCBLL1SLC26A3: 107,764,219–107,803,630, reverse strandSLC26A3DLD: 107,891,136–107,931,730, forward strandDLDLAMB1: 107,923,799–108,003,161, reverse strandLAMB1LAMB4: 108,023,548–108,130,367, reverse strandLAMB4NRCAM: 108,147,623–108,456,717, reverse strandNRCAMDiagram of LAMB1: 34 exons on the reverse strand of chromosome 7Exon 33: 2 known disease-causing sitesExon 28: 1 known disease-causing siteExon 26: 1 known disease-causing siteExon 25: 1 known disease-causing siteExon 22: 1 known disease-causing siteExon 16: 1 known disease-causing siteExon 15: 1 known disease-causing siteExon 13: 1 known disease-causing siteExon 10: 1 known disease-causing siteExon 9: 2 known disease-causing sitesExon 34: 107,923,799–107,924,087, 289 basesExon 33: 107,924,230–107,924,389, 160 basesExon 32: 107,926,183–107,926,359, 177 basesExon 31: 107,929,064–107,929,205, 142 basesExon 30: 107,929,412–107,929,619, 208 basesExon 29: 107,931,356–107,931,500, 145 basesExon 28: 107,932,174–107,932,377, 204 basesExon 27: 107,935,415–107,935,656, 242 basesExon 26: 107,937,093–107,937,277, 185 basesExon 25: 107,939,989–107,940,358, 370 basesExon 24: 107,951,226–107,951,322, 97 basesExon 23: 107,952,009–107,952,223, 215 basesExon 22: 107,953,530–107,953,754, 225 basesExon 21: 107,955,467–107,955,630, 164 basesExon 20: 107,959,249–107,959,480, 232 basesExon 19: 107,959,691–107,959,834, 144 basesExon 18: 107,960,445–107,960,649, 205 basesExon 17: 107,961,206–107,961,329, 124 basesExon 16: 107,961,549–107,961,676, 128 basesExon 15: 107,962,905–107,963,063, 159 basesExon 14: 107,964,552–107,964,687, 136 basesExon 13: 107,972,992–107,973,071, 80 basesExon 12: 107,974,986–107,975,098, 113 basesExon 11: 107,975,234–107,975,413, 180 basesExon 10: 107,975,689–107,975,877, 189 basesExon 9: 107,978,047–107,978,167, 121 basesExon 8: 107,980,609–107,980,811, 203 basesExon 7: 107,986,022–107,986,085, 64 basesExon 6: 107,986,175–107,986,363, 189 basesExon 5: 107,994,887–107,994,960, 74 basesExon 4: 107,998,357–107,998,492, 136 basesExon 3: 108,001,558–108,001,733, 176 basesExon 2: 108,002,849–108,002,971, 123 basesExon 1: 108,003,111–108,003,161, 51 bases343025201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.7 kb of the gene's 79.4 kb; 5,361 of those bases code for the protein.

How a genome test reads LAMB1

18

positions in LAMB1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 79.4 kb of LAMB1, introns included, not only the 5.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). LAMB1 gene: laminin subunit beta 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/lamb1

Vancouver

Dante Labs. LAMB1 gene: laminin subunit beta 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/lamb1

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