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Gene

LITAF

lipopolysaccharide induced TNF factor

Summary

Cytogenetic location
16p13.13
Coordinates
Chromosome 16: 11,547,722–11,586,919 (GRCh38)
Exons
4 exons across 39.2 kb
Protein
161 amino acids
Also known as
PIG7, SIMPLE, FLJ38636, TP53I7
MANE Select transcript
ENST00000622633.5NM_001136472.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Charcot-Marie-Tooth Disease

      • One of 62 genes linked to it

        A group of inherited peripheral neuropathies causing progressive weakness and wasting of the distal muscles and loss of sensation, mainly in the feet and hands.

        • ClinGen rates the link definitive
        • 3 GenCC submitters rate it definitive or strong
        What knowing changes

        Genetic counseling, subtype-specific monitoring, physical therapy, orthotics, neurotoxic drug avoidance, gene-specific clinical trials, surveillance for associated features

    How LITAF is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 16, with a bracket where LITAF sits. LITAF and 16 genes near it on chromosome 16, from 11,067,321 to 12,067,320.Chromosome 1616p13.13p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.311.2 Mb11.4 Mb11.6 Mb11.8 Mb12 MbCLEC16A: 10,944,508–11,189,745, forward strandCLEC16ASOCS1: 11,246,400–11,256,556, reverse strandRMI2: 11,249,619–11,381,662, forward strandRMI2TNP2: 11,267,748–11,269,533, reverse strandPRM3: 11,273,199–11,273,629, reverse strandPRM3PRM2: 11,275,632–11,276,488, reverse strandPRM2PRM1: 11,280,836–11,281,398, reverse strandPRM1APOLTP: 11,359,845–11,527,247, reverse strandAPOLTPLITAF: 11,547,722–11,586,919, reverse strandLITAFSNN: 11,668,027–11,679,164, forward strandSNNTXNDC11: 11,679,073–11,743,703, reverse strandTXNDC11ZC3H7A: 11,750,586–11,797,263, reverse strandZC3H7ARSL1D1: 11,833,850–11,851,586, reverse strandRSL1D1GSPT1: 11,868,128–11,916,082, reverse strandGSPT1NPIPB2: 11,927,259–11,976,643, reverse strandNPIPB2TNFRSF17: 11,965,138–11,968,068, forward strandTNFRSF17SNX29: 11,976,694–12,574,287, forward strandSNX29Diagram of LITAF: 4 exons on the reverse strand of chromosome 16Exon 4: 1 known disease-causing siteExon 3: 4 known disease-causing sitesExon 4: 11,547,722–11,549,745, 2,024 basesExon 3: 11,553,533–11,553,689, 157 basesExon 2: 11,556,511–11,556,735, 225 basesExon 1: 11,586,886–11,586,919, 34 bases43215′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 2.4 kb of the gene's 39.2 kb; 486 of those bases code for the protein.

    How a genome test reads LITAF

    5

    positions in LITAF where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 39.2 kb of LITAF, introns included, not only the 2.4 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). LITAF gene: lipopolysaccharide induced TNF factor. Retrieved 16 October 2026, from https://dantelabs.com/genes/litaf

    Vancouver

    Dante Labs. LITAF gene: lipopolysaccharide induced TNF factor [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/litaf

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