Gene

HOGA1

4-hydroxy-2-oxoglutarate aldolase 1

Cytogenetic location: 10q24.2
Coordinates: Chromosome 10: 97,584,389–97,612,802 (GRCh38)
Exons: 7 exons across 28.4 kb
Protein: 327 amino acids
Inheritance: Autosomal recessive
Also known as: FLJ37472, DHDPS2, NPL2
Previous symbols: C10orf65, DHDPSL
MANE Select transcript: ENST00000370646.9NM_138413.4
Locus type: gene with protein product

Very high
Confident
Low
Very low

Read HOGA1, and the rest of your genome, with one test.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test

Curated report relevant to this gene

Primary Hyperoxaluria
- Autosomal recessive
  A hereditary disorder characterized by excessive oxalate production, leading to hyperoxaluria.
  - ClinGen rates the link definitive
  - 5 GenCC submitters rate it definitive or strong

Inheritance

Autosomal recessive: It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How a genome test reads HOGA1

positions in HOGA1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 28.4 kb of HOGA1, introns included, not only the 2.4 kb of exons.

Traits linked to HOGA1

The Human Phenotype Ontology lists these as features of the rare conditions HOGA1 can cause. Each trait's page lists the other genes linked to it.

Abnormality of the genitourinary system

Laboratory abnormality

Constitutional symptom

Pain

External links

Gene records

Transcript

Protein

Variants

Clinical

Where this comes from

HGNC: the gene's symbol, name, other symbols and location.
MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
The ACMG secondary findings list, SF v3.2.
ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). HOGA1 gene: 4-hydroxy-2-oxoglutarate aldolase 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/hoga1

Vancouver

Dante Labs. HOGA1 gene: 4-hydroxy-2-oxoglutarate aldolase 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/hoga1

One test. A lifetime of answers.