Skip to content
Use your HSA or FSA funds

Gene

TIA1

TIA1 cytotoxic granule associated RNA binding protein

Summary

Cytogenetic location
2p13.3
Coordinates
Chromosome 2: 70,209,444–70,248,628 (GRCh38)
Exons
13 exons across 39.2 kb
Protein
386 amino acids
Also known as
TIA-1
MANE Select transcript
ENST00000433529.7NM_022173.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Distal Myopathies

    • Distal Myopathy, Welander Type

      Welander distal myopathy (WDM) is a distal myopathy, characterized by weakness in the distal upper extremities, usually finger and wrist extensors which later progresses to all hand muscles and distal lower extremity, primarily in toe and ankle extensors.

      • 1 GenCC submitter rates it definitive or strong
    • Distal myopathy

      A group of inherited muscle disorders in which weakness starts in the hands, forearms, lower legs or feet, caused by genes such as TTN, DYSF, FLNC, MYH7, ADSS1, SMPX and MATR3.

      • 1 GenCC submitter rates it definitive or strong

How TIA1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 2, with a bracket where TIA1 sits. TIA1 and 14 genes near it on chromosome 2, from 69,729,036 to 70,729,035.Chromosome 22p13.3p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.369.8 Mb70 Mb70.2 Mb70.4 Mb70.6 MbANXA4: 69,643,109–69,827,121, forward strandANXA4GMCL1: 69,829,612–69,881,393, forward strandGMCL1: 69,829,739–69,829,798, forward strandSNRNP27: 69,893,944–69,907,658, forward strandSNRNP27MXD1: 69,897,688–69,942,945, forward strandMXD1ASPRV1: 69,960,089–69,961,631, reverse strandASPRV1: 69,960,104–70,087,320, reverse strandPCBP1: 70,087,477–70,089,203, forward strandPCBP1C2orf42: 70,149,882–70,248,615, reverse strandC2orf42TIA1: 70,209,444–70,248,628, reverse strandTIA1PCYOX1: 70,257,386–70,281,185, forward strandPCYOX1SNRPG: 70,281,204–70,293,766, reverse strandSNRPGTIMCC: 70,295,975–70,302,086, reverse strandTIMCCTGFA: 70,447,284–70,554,193, reverse strandTGFAADD2: 70,607,618–70,768,499, reverse strandADD2Diagram of TIA1: 13 exons on the reverse strand of chromosome 2Exon 13: 1 known disease-causing siteExon 13: 70,209,444–70,212,845, 3,402 basesExon 12: 70,214,349–70,214,494, 146 basesExon 11: 70,215,371–70,215,494, 124 basesExon 10: 70,216,208–70,216,292, 85 basesExon 9: 70,216,404–70,216,499, 96 basesExon 8: 70,216,886–70,216,994, 109 basesExon 7: 70,224,554–70,224,629, 76 basesExon 6: 70,227,735–70,227,822, 88 basesExon 5: 70,229,059–70,229,091, 33 basesExon 4: 70,229,264–70,229,318, 55 basesExon 3: 70,230,756–70,230,854, 99 basesExon 2: 70,236,079–70,236,175, 97 basesExon 1: 70,248,405–70,248,628, 224 bases1310515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.6 kb of the gene's 39.2 kb; 1,161 of those bases code for the protein.

How a genome test reads TIA1

1

position in TIA1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 39.2 kb of TIA1, introns included, not only the 4.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TIA1 gene: TIA1 cytotoxic granule associated RNA binding protein. Retrieved 16 October 2026, from https://dantelabs.com/genes/tia1

Vancouver

Dante Labs. TIA1 gene: TIA1 cytotoxic granule associated RNA binding protein [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/tia1

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test