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Gene

ARMC5

armadillo repeat containing 5

Summary

Cytogenetic location
16p11.2
Coordinates
Chromosome 16: 31,459,501–31,467,165 (GRCh38)
Exons
6 exons across 7.7 kb
Protein
935 amino acids
Inheritance
Autosomal dominant
Also known as
FLJ13063
MANE Select transcript
ENST00000268314.9NM_001105247.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Carney Complex & Hereditary Adrenal Cushing Syndrome

    • ARMC5-related primary bilateral macronodular adrenal hyperplasiaAutosomal dominant

      Enlargement of both adrenal glands with multiple nodules that can slowly produce excess cortisol in adulthood.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Allows biochemical screening for cortisol excess in carriers and their relatives.

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How ARMC5 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 16, with a bracket where ARMC5 sits. ARMC5 and 28 genes near it on chromosome 16, from 30,963,333 to 31,963,332.Chromosome 1616p11.2p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.331 Mb31.2 Mb31.4 Mb31.6 Mb31.8 MbSETD1A: 30,957,294–30,984,664, forward strandSETD1AHSD3B7: 30,985,029–30,989,154, forward strandHSD3B7STX1B: 30,989,256–31,010,897, reverse strandSTX1BSTX4: 31,032,889–31,042,975, forward strandSTX4ZNF668: 31,059,772–31,074,240, reverse strandZNF646: 31,074,394–31,084,196, forward strandPRSS53: 31,083,437–31,089,628, reverse strand: 31,083,439–31,094,956, reverse strandVKORC1: 31,090,260–31,095,980, reverse strandBCKDK: 31,106,107–31,113,464, forward strandBCKDKKAT8: 31,114,489–31,131,396, forward strandKAT8PRSS8: 31,131,433–31,135,727, reverse strandPRSS8PRSS36: 31,138,926–31,150,213, reverse strandPRSS36FUS: 31,180,131–31,196,963, forward strandFUSPYCARD: 31,201,486–31,203,450, reverse strandPYCARDTRIM72: 31,214,017–31,231,537, forward strandTRIM72PYDC1: 31,215,962–31,217,162, reverse strandPYDC1ITGAM: 31,259,954–31,332,892, forward strandITGAMITGAX: 31,355,134–31,382,999, forward strandITGAXITGAD: 31,393,258–31,426,505, forward strandITGADCOX6A2: 31,427,731–31,428,433, reverse strandZNF843: 31,432,593–31,444,323, reverse strandZNF843ARMC5: 31,459,501–31,467,165, forward strandARMC5TGFB1I1: 31,471,585–31,478,727, forward strandTGFB1I1SLC5A2: 31,483,002–31,490,860, forward strandSLC5A2RUSF1: 31,489,465–31,509,309, reverse strandRUSF1AHSP: 31,512,938–31,528,808, forward strandAHSPKRABD5: 31,713,227–31,794,890, forward strandKRABD5ZNF267: 31,873,783–31,918,055, forward strandZNF267Diagram of ARMC5: 6 exons on the forward strand of chromosome 16Exon 1: 1 known disease-causing siteExon 3: 6 known disease-causing sitesExon 4: 3 known disease-causing sitesExon 6: 2 known disease-causing sitesExon 1: 31,459,501–31,459,999, 499 basesExon 2: 31,461,922–31,462,029, 108 basesExon 3: 31,462,131–31,462,917, 787 basesExon 4: 31,464,394–31,464,887, 494 basesExon 5: 31,465,850–31,465,982, 133 basesExon 6: 31,466,079–31,467,165, 1,087 bases1234565′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.1 kb of the gene's 7.7 kb; 2,808 of those bases code for the protein.

How a genome test reads ARMC5

12

positions in ARMC5 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 7.7 kb of ARMC5, introns included, not only the 3.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ARMC5 gene: armadillo repeat containing 5. Retrieved 16 October 2026, from https://dantelabs.com/genes/armc5

Vancouver

Dante Labs. ARMC5 gene: armadillo repeat containing 5 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/armc5

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