Trait
Extreme thirst
Clinical name: Polydipsia
Excessive thirst manifested by excessive fluid intake.
Summary
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
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Get my Genome Test52 genes linked to Extreme thirst
Changes in these genes cause rare conditions in which Extreme thirst is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AQP2aquaporin 2 | Always | In 2 conditions |
| AVPR2arginine vasopressin receptor 2 | Always | In 2 conditions |
| BBS2Bardet-Biedl syndrome 2 | Always | In 1 condition |
| BBS9Bardet-Biedl syndrome 9 | Always | In 1 condition |
| BSNDbarttin CLCNK type accessory subunit beta | Always | In 1 condition |
| CILK1ciliogenesis associated kinase 1 | Always | In 1 condition |
| NEK8NIMA related kinase 8 | Always | In 2 conditions |
| PAX4paired box 4 | Always | In 1 condition |
| SLC41A1solute carrier family 41 member 1 | Always | In 1 condition |
| AVParginine vasopressin | Very often (80–99%) | In 1 condition |
| CISD2CDGSH iron sulfur domain 2 | Very often (80–99%) | In 1 condition |
| CLDN16claudin 16 | Very often (80–99%) | In 1 condition |
| CTNScystinosin, lysosomal cystine transporter | Very often (80–99%) | In 3 conditions |
| WFS1wolframin ER transmembrane glycoprotein | Very often (80–99%) | In 1 condition |
| CACNA1Dcalcium voltage-gated channel subunit alpha1 D | Often (30–79%) | In 1 condition |
| CDC73cell division cycle 73 | Often (30–79%) | In 2 conditions |
| DCDC2doublecortin domain containing 2 | Often (30–79%) | In 1 condition |
| HSD11B2hydroxysteroid 11-beta dehydrogenase 2 | Often (30–79%) | In 1 condition |
| KCNJ10potassium inwardly rectifying channel subfamily J member 10 | Often (30–79%) | In 2 conditions |
| LZTFL1leucine zipper transcription factor like 1 | Often (30–79%) | In 1 condition |
| NPHP1nephrocystin 1 | Often (30–79%) | In 2 conditions |
| NPHP3nephrocystin 3 | Often (30–79%) | In 1 condition |
| TMEM67transmembrane protein 67 | Often (30–79%) | In 2 conditions |
| ARNT2aryl hydrocarbon receptor nuclear translocator 2 | Sometimes (5–29%) | In 1 condition |
| CD4CD4 molecule | Sometimes (5–29%) | In 1 condition |
| CYP11B1cytochrome P450 family 11 subfamily B member 1 | Sometimes (5–29%) | In 1 condition |
| CYP11B2cytochrome P450 family 11 subfamily B member 2 | Sometimes (5–29%) | In 1 condition |
| DZIP1LDAZ interacting zinc finger protein 1 like | Sometimes (5–29%) | In 1 condition |
| FGFR1fibroblast growth factor receptor 1 | Sometimes (5–29%) | In 1 condition |
| HESX1HESX homeobox 1 | Sometimes (5–29%) | In 1 condition |
| HNF1BHNF1 homeobox B | Sometimes (5–29%) | In 1 condition |
| HPSE2heparanase 2 (inactive) | Sometimes (5–29%) | In 1 condition |
| INSRinsulin receptor | Sometimes (5–29%) | In 1 condition |
| IRF4interferon regulatory factor 4 | Sometimes (5–29%) | In 1 condition |
| KCNJ5potassium inwardly rectifying channel subfamily J member 5 | Sometimes (5–29%) | In 2 conditions |
| LRIG2leucine rich repeats and immunoglobulin like domains 2 | Sometimes (5–29%) | In 1 condition |
| NLRP3NLR family pyrin domain containing 3 | Sometimes (5–29%) | In 1 condition |
| OTX2orthodenticle homeobox 2 | Sometimes (5–29%) | In 1 condition |
| PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin | Sometimes (5–29%) | In 1 condition |
| PROKR2prokineticin receptor 2 | Sometimes (5–29%) | In 1 condition |
Show 12 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| SOX2SRY-box transcription factor 2 | Sometimes (5–29%) | In 1 condition |
| SOX3SRY-box transcription factor 3 | Sometimes (5–29%) | In 1 condition |
| TRANK1tetratricopeptide repeat and ankyrin repeat containing 1 | Sometimes (5–29%) | In 1 condition |
| CLCNKBchloride voltage-gated channel Kb | Rarely (1–4%) | In 1 condition |
| SLC12A3solute carrier family 12 member 3 | Rarely (1–4%) | In 2 conditions |
| CASRcalcium sensing receptor | Not recorded | In 1 condition |
| CLDN10claudin 10 | Not recorded | In 1 condition |
| HNF1AHNF1 homeobox A | Not recorded | In 1 condition |
| IL6interleukin 6 | Not recorded | In 1 condition |
| KCNJ1potassium inwardly rectifying channel subfamily J member 1 | Not recorded | In 1 condition |
| NPHP4nephrocystin 4 | Not recorded | In 2 conditions |
| SLC5A2solute carrier family 5 member 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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