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Trait

Increased mobility in finger joint

Clinical name: Finger joint hypermobility

HPO HP:0006094

Summary

Body system
Abnormality of limbsAbnormality of the musculoskeletal system

19 genes linked to Increased mobility in finger joint

Changes in these genes cause rare conditions in which Increased mobility in finger joint is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
B3GALT6beta-1,3-galactosyltransferase 6AlwaysIn 2 conditions
COL1A1collagen type I alpha 1 chainAlwaysIn 1 condition
COL3A1collagen type III alpha 1 chainAlwaysIn 1 condition
COL6A2collagen type VI alpha 2 chainAlwaysIn 1 condition
CSGALNACT1chondroitin sulfate N-acetylgalactosaminyltransferase 1AlwaysIn 1 condition
ERI1exoribonuclease 1AlwaysIn 1 condition
ESAMendothelial cell adhesion moleculeAlwaysIn 1 condition
HIVEP2HIVEP zinc finger 2AlwaysIn 1 condition
NLRP1NLR family pyrin domain containing 1AlwaysIn 1 condition
P4HTMprolyl 4-hydroxylase, transmembraneAlwaysIn 1 condition
PPIBpeptidylprolyl isomerase BAlwaysIn 1 condition
RAB3GAP2RAB3 GTPase activating non-catalytic protein subunit 2AlwaysIn 1 condition
SLC13A1solute carrier family 13 member 1AlwaysIn 1 condition
CBLCbl proto-oncogeneOften (30–79%)In 1 condition
HYAL1hyaluronidase 1Often (30–79%)In 1 condition
COMPcartilage oligomeric matrix proteinSometimes (5–29%)In 1 condition
PROKR2prokineticin receptor 2Sometimes (5–29%)In 1 condition
RNF13ring finger protein 13Sometimes (5–29%)In 1 condition
YY1YY1 transcription factorSometimes (5–29%)In 2 conditions

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Abnormalities of the fingersAbnormality of hand joint mobilitySmall joint hypermobility

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

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