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Trait

Extrapyramidal muscular rigidity

Muscular rigidity (continuous contraction of muscles with constant resistance to passive movement).

HPO HP:0007076

Summary

Body system
Abnormality of the musculoskeletal systemAbnormality of the nervous system

13 genes linked to Extrapyramidal muscular rigidity

Changes in these genes cause rare conditions in which Extrapyramidal muscular rigidity is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
ADARadenosine deaminase RNA specificOften (30–79%)In 1 condition
ATP6AP2ATPase H+ transporting accessory protein 2Often (30–79%)In 1 condition
IFIH1interferon induced with helicase C domain 1Often (30–79%)In 1 condition
LSM11LSM11, U7 small nuclear RNA associatedOften (30–79%)In 1 condition
RNASEH2Aribonuclease H2 subunit AOften (30–79%)In 1 condition
RNASEH2Bribonuclease H2 subunit BOften (30–79%)In 1 condition
RNASEH2Cribonuclease H2 subunit COften (30–79%)In 1 condition
RNU7-1RNA, U7 small nuclear 1Often (30–79%)In 1 condition
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1Often (30–79%)In 1 condition
TREX1three prime repair exonuclease 1Often (30–79%)In 1 condition
OPA3outer mitochondrial membrane lipid metabolism regulator OPA3Sometimes (5–29%)In 1 condition
HLA-DQB1major histocompatibility complex, class II, DQ beta 1Not recordedIn 1 condition
PRNPprion protein (Kanno blood group)Not recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Abnormality of extrapyramidal motor functionRigidity

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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