Trait
Peripheral nerve disease
Clinical name: Polyneuropathy
A generalized disorder of peripheral nerves.
Summary
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test75 genes linked to Peripheral nerve disease
Changes in these genes cause rare conditions in which Peripheral nerve disease is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ABCC8ATP binding cassette subfamily C member 8 | Always | In 1 condition |
| ARHGAP19Rho GTPase activating protein 19 | Always | In 1 condition |
| ATXN10ataxin 10 | Always | In 1 condition |
| B2Mbeta-2-microglobulin | Always | In 1 condition |
| COX18cytochrome c oxidase assembly factor COX18 | Always | In 1 condition |
| DHHdesert hedgehog signaling molecule | Always | In 2 conditions |
| DMXL2Dmx like 2 | Always | In 1 condition |
| ERCC6ERCC excision repair 6, chromatin remodeling factor | Always | In 1 condition |
| FDXRferredoxin reductase | Always | In 1 condition |
| ITPR3inositol 1,4,5-trisphosphate receptor type 3 | Always | In 1 condition |
| KLC4kinesin light chain 4 | Always | In 1 condition |
| LITAFlipopolysaccharide induced TNF factor | Always | In 1 condition |
| MPV17mitochondrial inner membrane protein MPV17 | Always | In 1 condition |
| NDC1NDC1 transmembrane nucleoporin | Always | In 1 condition |
| NGLY1N-glycanase 1 | Always | In 1 condition |
| PEX7peroxisomal biogenesis factor 7 | Always | In 1 condition |
| PSAPprosaposin | Always | In 1 condition |
| PTCRApre T cell antigen receptor alpha | Always | In 1 condition |
| RAB32RAB32, member RAS oncogene family | Always | In 1 condition |
| RNU6ATACRNA, U6atac small nuclear | Always | In 1 condition |
| TBC1D24TBC1 domain family member 24 | Always | In 1 condition |
| TBCBtubulin folding cofactor B | Always | In 1 condition |
| HYCC1hyccin PI4KA lipid kinase complex subunit 1 | Very often (80–99%) | In 1 condition |
| SEPTIN9septin 9 | Very often (80–99%) | In 1 condition |
| TTRtransthyretin | Very often (80–99%) | In 3 conditions |
| UQCRC1ubiquinol-cytochrome c reductase core protein 1 | Very often (80–99%) | In 1 condition |
| AIFM1apoptosis inducing factor mitochondria associated 1 | Often (30–79%) | In 1 condition |
| ARL6IP1ARL6 interacting reticulophagy regulator 1 | Often (30–79%) | In 1 condition |
| GSNgelsolin | Often (30–79%) | In 2 conditions |
| MTRFRmitochondrial translation release factor in rescue | Often (30–79%) | In 1 condition |
| PSMC3proteasome 26S subunit, ATPase 3 | Often (30–79%) | In 1 condition |
| ALADaminolevulinate dehydratase | Sometimes (5–29%) | In 1 condition |
| ATP7BATPase copper transporting beta | Sometimes (5–29%) | In 1 condition |
| BCKDKbranched chain keto acid dehydrogenase kinase | Sometimes (5–29%) | In 1 condition |
| COQ4coenzyme Q4 | Sometimes (5–29%) | In 1 condition |
| GRM1glutamate metabotropic receptor 1 | Sometimes (5–29%) | In 2 conditions |
| NF1neurofibromin 1 | Sometimes (5–29%) | In 1 condition |
| NF2NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor | Sometimes (5–29%) | In 1 condition |
| PDYNprodynorphin | Sometimes (5–29%) | In 1 condition |
| CYP7B1cytochrome P450 family 7 subfamily B member 1 | Rarely (1–4%) | In 1 condition |
Show 35 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| DARS2aspartyl-tRNA synthetase 2, mitochondrial | Rarely (1–4%) | In 1 condition |
| NAGSN-acetylglutamate synthase | Rarely (1–4%) | In 1 condition |
| SPTBN1spectrin beta, non-erythrocytic 1 | Rarely (1–4%) | In 1 condition |
| SYNE1spectrin repeat containing nuclear envelope protein 1 | Rarely (1–4%) | In 1 condition |
| TMEM70transmembrane protein 70 | Rarely (1–4%) | In 1 condition |
| ABCD1ATP binding cassette subfamily D member 1 | Not recorded | In 1 condition |
| CD59CD59 molecule (CD59 blood group) | Not recorded | In 1 condition |
| COQ7coenzyme Q7, hydroxylase | Not recorded | In 1 condition |
| DGUOKdeoxyguanosine kinase | Not recorded | In 1 condition |
| EDNRBendothelin receptor type B | Not recorded | In 1 condition |
| ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit | Not recorded | In 1 condition |
| FUCA1alpha-L-fucosidase 1 | Not recorded | In 1 condition |
| HLA-DQA1major histocompatibility complex, class II, DQ alpha 1 | Not recorded | In 1 condition |
| HLA-DQB1major histocompatibility complex, class II, DQ beta 1 | Not recorded | In 1 condition |
| LDB3LIM domain binding 3 | Not recorded | In 1 condition |
| MT-ATP6mitochondrially encoded ATP synthase membrane subunit 6 | Not recorded | In 1 condition |
| MT-CO3mitochondrially encoded cytochrome c oxidase III | Not recorded | In 1 condition |
| MT-CYBmitochondrially encoded cytochrome b | Not recorded | In 1 condition |
| MT-ND1mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 | Not recorded | In 1 condition |
| MT-ND2mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 | Not recorded | In 1 condition |
| MT-ND4mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 | Not recorded | In 1 condition |
| MT-ND4Lmitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L | Not recorded | In 1 condition |
| MT-ND5mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 | Not recorded | In 1 condition |
| MT-ND6mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 | Not recorded | In 1 condition |
| MYD88MYD88 innate immune signal transduction adaptor | Not recorded | In 1 condition |
| MYOTmyotilin | Not recorded | In 1 condition |
| OPA1OPA1 mitochondrial dynamin like GTPase | Not recorded | In 1 condition |
| PEX11Bperoxisomal biogenesis factor 11 beta | Not recorded | In 1 condition |
| PEX12peroxisomal biogenesis factor 12 | Not recorded | In 1 condition |
| PMM2phosphomannomutase 2 | Not recorded | In 1 condition |
| PRPS1phosphoribosyl pyrophosphate synthetase 1 | Not recorded | In 1 condition |
| RPIAribose 5-phosphate isomerase A | Not recorded | In 1 condition |
| SETXsenataxin | Not recorded | In 1 condition |
| SLC12A6solute carrier family 12 member 6 | Not recorded | In 1 condition |
| SNAP29synaptosome associated protein 29 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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