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Gene

HLA-DRB5

major histocompatibility complex, class II, DR beta 5

Summary

Cytogenetic location
6p21.32
Coordinates
Chromosome 6: 32,517,353–32,530,287 (GRCh38)
Exons
6 exons across 12.9 kb
Protein
266 amino acids
MANE Select transcript
ENST00000374975.4NM_002125.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads HLA-DRB5 yet. The test sequences your whole genome, so your data includes it all the same.

How HLA-DRB5 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 6, with a bracket where HLA-DRB5 sits. HLA-DRB5 and 35 genes near it on chromosome 6, from 32,023,820 to 33,023,819.Chromosome 66p21.32p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q2732.2 Mb32.4 Mb32.6 Mb32.8 Mb33 MbC4B: 32,014,725–32,035,975, forward strandC4BCYP21A2: 32,038,297–32,042,321, forward strandCYP21A2TNXB: 32,041,153–32,115,334, reverse strandTNXBATF6B: 32,115,264–32,128,255, reverse strandATF6BFKBPL: 32,128,697–32,131,070, reverse strandPPT2: 32,146,580–32,163,679, forward strandPRRT1: 32,147,292–32,153,083, reverse strand: 32,150,495–32,154,373, reverse strandPPT2-EGFL8: 32,153,845–32,171,978, forward strandEGFL8: 32,163,918–32,171,980, forward strandAGPAT1: 32,167,118–32,178,112, reverse strandRNF5: 32,178,391–32,184,769, forward strandAGER: 32,180,963–32,184,365, reverse strandAGERPBX2: 32,184,733–32,190,278, reverse strandPBX2GPSM3: 32,190,766–32,195,523, reverse strandGPSM3NOTCH4: 32,194,843–32,224,111, reverse strandNOTCH4TSBP1: 32,288,526–32,371,907, reverse strandTSBP1BTNL2: 32,391,481–32,407,181, reverse strandBTNL2HLA-DRA: 32,439,870–32,445,181, forward strandHLA-DRAHLA-DRB5: 32,517,353–32,530,287, reverse strandHLA-DRB5HLA-DRB1: 32,577,902–32,589,848, reverse strandHLA-DRB1HLA-DQA1: 32,628,179–32,659,533, forward strandHLA-DQA1HLA-DQB1: 32,640,622–32,668,383, reverse strandHLA-DQB1HLA-DQA2: 32,741,391–32,747,198, forward strandHLA-DQA2HLA-DQB2: 32,756,094–32,763,563, reverse strandHLA-DQB2HLA-DOB: 32,812,763–32,820,466, reverse strandHLA-DOB: 32,813,767–32,838,822, reverse strandTAP2: 32,821,833–32,838,802, reverse strandTAP2PSMB8: 32,840,717–32,844,679, reverse strandPSMB8PSMB9: 32,844,136–32,882,881, forward strandTAP1: 32,845,204–32,854,026, reverse strandHLA-DMB: 32,929,338–32,941,490, reverse strandHLA-DMB: 32,937,364–32,953,122, reverse strandHLA-DMA: 32,948,613–32,969,094, reverse strandHLA-DMABRD2: 32,968,564–32,981,505, forward strandBRD2HLA-DOA: 33,004,178–33,009,617, reverse strandHLA-DOADiagram of HLA-DRB5: 6 exons on the reverse strand of chromosome 6Exon 6: 32,517,353–32,517,752, 400 basesExon 5: 32,518,054–32,518,077, 24 basesExon 4: 32,518,556–32,518,666, 111 basesExon 3: 32,519,370–32,519,651, 282 basesExon 2: 32,521,905–32,522,174, 270 basesExon 1: 32,530,125–32,530,287, 163 bases6543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.3 kb of the gene's 12.9 kb; 801 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.

Cite this page

APA

Dante Labs. (n.d.). HLA-DRB5 gene: major histocompatibility complex, class II, DR beta 5. Retrieved 17 October 2026, from https://dantelabs.com/genes/hla-drb5

Vancouver

Dante Labs. HLA-DRB5 gene: major histocompatibility complex, class II, DR beta 5 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/hla-drb5

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