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Gene

HLA-DMA

major histocompatibility complex, class II, DM alpha

Summary

Cytogenetic location
6p21.32
Coordinates
Chromosome 6: 32,948,618–32,953,097 (GRCh38)
Exons
5 exons across 4.5 kb
Protein
261 amino acids
Also known as
D6S222E, RING6
MANE Select transcript
ENST00000374843.9NM_006120.4
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads HLA-DMA yet. The test sequences your whole genome, so your data includes it all the same.

How HLA-DMA is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 6, with a bracket where HLA-DMA sits. HLA-DMA and 38 genes near it on chromosome 6, from 32,450,858 to 33,450,857.Chromosome 66p21.32p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q2732.6 Mb32.8 Mb33 Mb33.2 Mb33.4 MbHLA-DRB5: 32,516,622–32,530,369, reverse strandHLA-DRB5HLA-DRB1: 32,577,902–32,589,848, reverse strandHLA-DRB1HLA-DQA1: 32,628,179–32,659,533, forward strandHLA-DQA1HLA-DQB1: 32,640,622–32,668,383, reverse strandHLA-DQB1HLA-DQA2: 32,741,391–32,747,198, forward strandHLA-DQA2HLA-DQB2: 32,756,094–32,763,563, reverse strandHLA-DQB2HLA-DOB: 32,812,763–32,820,466, reverse strand: 32,813,767–32,838,822, reverse strandTAP2: 32,821,833–32,838,802, reverse strandTAP2PSMB8: 32,840,717–32,844,679, reverse strandPSMB8PSMB9: 32,844,136–32,882,881, forward strandPSMB9TAP1: 32,845,204–32,854,026, reverse strandTAP1HLA-DMB: 32,929,338–32,941,490, reverse strandHLA-DMB: 32,937,364–32,953,122, reverse strandHLA-DMA: 32,948,618–32,953,097, reverse strandHLA-DMABRD2: 32,968,564–32,981,505, forward strandBRD2HLA-DOA: 33,004,178–33,009,617, reverse strandHLA-DOAHLA-DPA1: 33,064,569–33,080,781, reverse strandHLA-DPA1HLA-DPB1: 33,073,786–33,091,655, forward strandHLA-DPB1COL11A2: 33,162,681–33,192,802, reverse strandCOL11A2RXRB: 33,193,585–33,200,693, reverse strandRXRBSLC39A7: 33,200,305–33,204,439, forward strandSLC39A7HSD17B8: 33,204,631–33,206,831, forward strandHSD17B8RING1: 33,208,033–33,212,722, forward strandVPS52: 33,250,272–33,272,047, reverse strandVPS52RPS18: 33,271,730–33,276,513, forward strandRPS18B3GALT4: 33,277,123–33,284,832, forward strandB3GALT4WDR46: 33,279,103–33,289,523, reverse strandWDR46PFDN6: 33,288,680–33,298,441, forward strandRGL2: 33,291,180–33,299,534, reverse strandTAPBP: 33,299,694–33,314,284, reverse strandZBTB22: 33,314,406–33,318,021, reverse strandDAXX: 33,318,558–33,323,259, reverse strand: 33,321,386–33,329,286, reverse strandSMIM40: 33,323,628–33,329,279, reverse strandKIFC1: 33,391,429–33,410,441, forward strandKIFC1PHF1: 33,410,360–33,416,453, forward strandPHF1CUTA: 33,416,442–33,418,381, reverse strandCUTASYNGAP1: 33,419,661–33,453,689, forward strandSYNGAP1Diagram of HLA-DMA: 5 exons on the reverse strand of chromosome 6Exon 5: 32,948,618–32,948,868, 251 basesExon 4: 32,949,271–32,949,399, 129 basesExon 3: 32,949,611–32,949,889, 279 basesExon 2: 32,950,519–32,950,803, 285 basesExon 1: 32,952,949–32,953,097, 149 bases543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.1 kb of the gene's 4.5 kb; 786 of those bases code for the protein.

Sequencing HLA-DMA

1Easy

How hard HLA-DMA is to sequence with short reads, out of 100

Almost all of HLA-DMA's exons sit where short reads map cleanly.

What adds to it: the share of HLA-DMA's exons in each kind of hard region

  • Mappability0%
  • Homology0%
  • Shared with chrY0%
  • Reference coverage0%
  • Repeats1.8%
  • GC content0%

A Dante Labs score from our own research, built on NIST's Genome in a Bottle maps of hard-to-sequence regions.How it's scored

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • The Genome in a Bottle genome stratifications, from NIST: the sequencing difficulty score.

Cite this page

APA

Dante Labs. (n.d.). HLA-DMA gene: major histocompatibility complex, class II, DM alpha. Retrieved 20 October 2026, from https://dantelabs.com/genes/hla-dma

Vancouver

Dante Labs. HLA-DMA gene: major histocompatibility complex, class II, DM alpha [Internet]. [cited 20 October 2026]. Available from: https://dantelabs.com/genes/hla-dma

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